甲氧氯普胺联合铝碳酸镁治疗妊娠剧吐临床研究OA

Objective To investigate the clinical efficacy of metoclopramide combined with magnesium aluminum carbonate in the treatment of hyperemesis gravidarum.Methods A total of 110 patients with hyperemesis gravidarum admitted to the Xingtai Central Hospital from October 2020 to October 2024 were selected and divided into the observation group and the control group by the random number table method,with 55 cases in each group.The patients in the two groups were treated routine fluid replacement and metoclopramide,while the patients in the observation group treated additionally with magnesium aluminum carbonate.Both groups were treated continuously for 7 d.Results The total effective rate in the observation group was 96.36%,which was significantly higher than 83.64%in the control group(P<0.05).The hospitalization time,cure time,antiemetic time,and conversion time of urinary ketone in the observation group were significantly shorter than those in the control group(P<0.05).After treatment,the Nausea and Vomiting of Pregnancy Quality of Life(NVPQOL)item scores,Self-Rating Anxiety Scale(SAS)scores,Self-Rating Depression Scale(SDS)scores,and β-human chorionic gonadotropin(β-hCG)levels in the two groups significantly reduced(P<0.05),and those in the observation group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was comparable to that in the control group(12.73%vs.7.27%,P>0.05).Conclusion Metoclopramide combined with magnesium aluminum carbonate has a good clinical efficacy and safety in the treatment of preeclampsia,which can shorten the patients' recovery time,effectively alleviate their anxiety and depression,improve their quality of life,and reduce serum β-hCG levels.