化瘀通络法通过调控Janus激酶2/信号转导与转录激活因子3信号通路介导的炎性反应治疗慢性萎缩性胃炎临床研究OA
Clinical Study of Huayu Tongluo Method in the Treatment of Chronic Atrophic Gastritis by Regulating JAK2/STAT3 Signaling Pathway-Mediated Inflammatory Response
目的 探讨化瘀通络法通过调控Janus激酶 2(JAK2)/信号转导与转录激活因子 3(STAT3)信号通路介导炎性反应治疗慢性萎缩性胃炎(CAG)的临床疗效.方法 选取医院 2022 年 4 月至 2024 年 4 月收治的CAG患者 86 例,按随机数字表法分为治疗组和对照组,各 43 例.两组患者均予标准四联疗法(阿莫西林+克拉霉素+铋剂+奥美拉唑)治疗,治疗组患者在此基础上加用化瘀通络法(化瘀通络方加减),两组患者均连续治疗 14 d.结果 治疗组总有效率为 86.05%,显著高于对照组的 60.47%(P<0.05).治疗后,两组患者的中医证候积分和胃黏膜病理评分均显著降低(P<0.05),且治疗组均显著低于对照组(P<0.05);两组患者的血清胃蛋白酶原(PG)Ⅰ、PGⅠ/PGⅡ、胃泌素 17(G-17)水平均显著升高(P<0.05),PGⅡ水平均显著降低(P<0.05),且治疗组均显著优于对照组(P<0.05);两组患者的胃黏膜组织JAK2 mRNA,STAT3 mRNA相对表达量和血清白细胞介素 6、肿瘤坏死因子-α水平均显著降低(P<0.05),且治疗组均显著低于对照组(P<0.05).结论 化瘀通络法可通过调控JAK2/STAT3 信号通路介导的炎性反应抑制胃黏膜的炎症损伤,促进胃黏膜的修复、再生,提高胃黏膜的防御功能,从而治疗CAG.
Objective To investigate the clinical efficacy of Huayu Tongluo method in the treatment of chronic atrophic gastritis(CAG)by regulating the Janus kinase 2(JAK2)/signal transducer and activators of transcription 3(STAT3)signaling pathway-mediated inflammatory response.Methods A total of 86 patients with CAG admitted to the hospital from April 2022 to April 2024 were selected and divided into the treatment group and the control group by the random number table method,with 43 cases in each group.The patients in the two groups were treated with standard quadruple therapy(amoxicillin+clarithromycin+bismuth+omeprazole),and the patients in the treatment group were treated additionally with the Huayu Tongluo method(modified Huayu Tongluo Formula).Both groups were treated continuously for 14 d.Results The total effective rate in the treatment group was 86.05%,which was significantly higher than 60.47%in the control group(P<0.05).After treatment,the traditional Chinese medicine(TCM)syndrome scores and gastric mucosal pathology scores in the two groups significantly reduced(P<0.05),and those in the treatment group were significantly lower than those in the control group(P<0.05);the levels of serum pepsinogen(PG)Ⅰ,PG Ⅰ/PG Ⅱ,and gastrin 17(G-17)in the two groups significantly increased(P<0.05),while the levels of PG Ⅱin the two groups significantly decreased(P<0.05),and those in the treatment group were significantly better than those in the control group(P<0.05);the relative expression levels of JAK2 mRNA and STAT3 mRNA in gastric mucosal tissue,and the serum levels of interleukin-6 and tumor necrosis factor-α in the two groups significantly reduced(P<0.05),and those in the treatment group were significantly lower than those in the control group(P<0.05).Conclusion Huayu Tongluo method can inhibit the inflammatory damage of gastric mucosa by regulating the JAK2/STAT3 signaling pathway-mediated the inflammatory response,promote the repair and regeneration of gastric mucosa,improve the defense function of gastric mucosa,and thus achieve the purpose of treating CAG.
陈晓;刘春倩;刘银鸿
河北省衡水市中医医院,河北 衡水 053000河北省衡水市中医医院,河北 衡水 053000河北省衡水市中医医院,河北 衡水 053000
医药卫生
化瘀通络法慢性萎缩性胃炎Janus激酶2/信号转导与转录激活因子3信号通路炎性反应
Huayu Tongluo methodchronic atrophic gastritisJAK2/STAT3 signaling pathwayinflammatory response
《中国药业》 2026 (3)
108-112,5
河北省中医药管理局科研计划项目[2025177,2018551].
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