散结镇痛胶囊联合左炔诺孕酮宫内缓释节育系统治疗子宫腺肌病临床研究OA

Objective To investigate the clinical efficacy of Sanjie Zhitong Capsules combined with Levonorgestrel-Releasing Intrauterine System(LNG-IUS)in the treatment of adenomyosis.Methods A retrospective study was conducted on 120 patients with adenomyosis admitted to the Suqian Hospital Affiliated to Xuzhou Medical University from June 2023 to October 2024.The patients were divided into the study group and the control group according to different treatment methods,with 60 cases in each group.The patients in the two groups received LNG-IUS treatment,while the patients in the study group were treated additionally with Sanjie Zhitong Capsules.Both groups were treated continously with six months.Results The total effective rate in the study group was 96.67%,which was significantly higher than 81.67%in the control group(P<0.05).After treatment,the uterine volume in the study group was significantly smaller than that in the control group(P<0.05);the traditional Chinese medicine(TCM)syndrome score,the Visual Analog Scale(VAS)score,the Pictorial Blood Loss Assessment Chart(PBAC)score,and the levels of serum carbohydrate antigen 125(CA125),interleukin-6(IL-6),angiopoietin 2(Ang-2),vascular endothelial growth factor(VEGF),transforming growth factor-β1(TGF-β1),and insulin-like growth factor 1(IGF-1)in the study group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions in the study group and control group patients was comparable(5.00%vs.10.00%,P>0.05).Conclusion Sanjie Zhitong Capsules combined with LNG-IUS have a good efficacy and safety in the treatment of adenomyosis,which can effectively improve the TCM syndrome,reduce uterine volume,alleviate dysmenorrhea,and reduce menstrual flow and the levels of serum CA125,IL-6,Ang-2,VEGF,TGF-β1,and IGF-1.