高压脉冲电场消融中电极几何参数与组织介电特性对阻抗测量灵敏度的影响研究OA
Effects of electrode geometric parameters and tissue dielectric properties on sensitivity of impedance measurements in high-voltage pulsed electric field ablation
目的:研究高压脉冲电场消融中电极几何参数与组织介电特性对阻抗测量灵敏度的影响,从而为高压脉冲电场消融中阻抗谱测量电极对的选择提供理论依据.方法:首先,基于COMSOL Multiphysics 6.2构建三维模型,在均匀组织条件下仿真高压脉冲电场消融中不同组织介电参数(电导率σ和相对介电常数εr)、电极间距与电极暴露长度时的电流场分布.其次,使用阈值分割算法量化阻抗测量灵敏度分布的空间特征,并分析阻抗有效测量区域的阻抗测量灵敏度分布.最后,通过在模型中设置不同电导率梯度的扰动区域仿真非均匀组织,研究组织异质性对阻抗测量灵敏度的影响规律.结果:均匀组织介电参数(σ和εr)的变化对阻抗测量灵敏度分布无显著影响;电极间距与阻抗有效测量区域面积呈正相关,但当间距超过4.0 cm时阻抗测量灵敏度显著下降;电极暴露长度与阻抗有效测量区域纵切面面积呈正相关.在非均匀组织中,局部电导率升高会显著提升该区域的阻抗测量灵敏度.结论:该研究揭示了高压脉冲电场消融中电极几何参数与组织介电特性对阻抗测量灵敏度的定量影响规律,为不可逆电穿孔治疗中阻抗谱测量时的电极对选择提供了参考.
Objective To investigate the effects of electrode geometric parameters and tissue dielectric properties on impedance measurement sensitivity during high-voltage pulsed electric field ablation,thereby providing a theoretical basis for selecting electrode pairs for impedance spectrum measurement in this procedure.Methods Firstly,a three-dimensional finite element model was established based on COMSOL Multiphysics 6.2 to simulate the current density field under homogeneous tissue conditions by varying key parameters such as tissue conductivity,relative permittivity,electrode spacing and exposure length.Subsequently,the spatial characteristics of the sensitivity distribution were quantified using a threshold segmentation algorithm,and the sensitivity distribution within the impedance-effective measurement region was analyzed.Finally,the influence of tissue heterogeneity on the sensitivity distribution was systematically investigated by introducing perturbation zones with different conductivity gradients into the model to simulate heterogeneous tissue conditions.Results Variations in the dielectric parameters(σ,εr)of homogeneous tissue showed no significant effects on the distribution of impedance measurement sensitivity.Electrode spacing was positively correlated with the area of the effective impedance measurement region,while measurement sensitivity decreased significantly when the spacing exceeded 4.0 cm;electrode exposure length was positively correlated with the cross-sectional area of the effective impedance measurement region in the longitudinal plane.In heterogeneous tissue,an increase in local conductivity significantly enhanced the impedance measurement sensitivity in that region.Conclusion The quantitative influences of tissue dielectric parameters and electrode geometric parameters on the effective impedance measurement area are revealed during high-voltage pulsed electric field ablation,providing references for selecting electrode pairs for impedance spectrum measurement in irreversible electroporation therapy.[Chinese Medical Equipment Journal,2026,47(1):14-20].
宋汝腾;刘本源;李俊瑶;朱明旭;马强;季振宇
空军军医大学军事生物医学工程学系,西安 710032陕西省生物电磁检测与智能感知重点实验室,西安 710032空军军医大学军事生物医学工程学系,西安 710032陕西省生物电磁检测与智能感知重点实验室,西安 710032空军军医大学军事生物医学工程学系,西安 710032陕西省生物电磁检测与智能感知重点实验室,西安 710032
医药卫生
高压脉冲电场消融阻抗测量灵敏度阻抗有效测量区域电极几何参数组织介电特性
high-voltage pulsed electric field ablationimpedance measurement sensitivityeffective impedance measure-ment areaelectrode geometric parametertissue dielectric parameter
《医疗卫生装备》 2026 (1)
14-20,7
国家重点研发计划项目(2019YFC0119103)
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