脑小血管病抑郁患者血清LDH、MCP-1、TCF4水平检测及其临床意义OA

Objective To explore the changes in serum lactate dehydrogenase(LDH),monocyte chemoattractant protein-1(MCP-1),and transcription factor 4(TCF4)levels in patients with cerebral small vessel disease complicated by depression and their clinical significance.Methods According to the inclusion and exclusion criteria,90 patients admit-ted to the Kailuan General Hospital between January 2022 and August 2024 were selected as the study subjects,including 27 patients diagnosed with cerebral small vessel disease complicated by depression and 63 patients with cerebral small ves-sel disease uncomplicated by depression.An additional 45 healthy individuals with normal head MRI findings and no men-tal disorders during the same period at the hospital were selected as the control group.General information was collected from the three groups,including age,body mass index,systolic blood pressure,and diastolic blood pressure.The general information and the levels of serum LDH,MCP-1,and TCF4 in the three groups were compared.The correlations of serum LDH,MCP-1,and TCF4 levels with HAMD score in patients with cerebral small vessel disease and depression were ana-lyzed.Logistic regression was applied to analyze possible factors leading to depression in patients with cerebral small ves-sel disease.The receiver operating characteristic curve was applied to analyze the efficacy of serum LDH,MCP-1,and TCF4 levels in diagnosing depression in patients with cerebral small vessel disease.Results The levels of serum LDH,MCP-1,and TCF4 were significantly higher in the cerebral small vessel disease complicated by depression group than in ce-rebral small vessel disease uncomplicated with depression group and the control group(P<0.05),and these levels were significantly higher in the cerebral small vessel disease uncomplicated with depression group than in the control group(P<0.05).The serum LDH,MCP-1 and TCF4 were positively correlated with HAMD score in patients with cerebral small ves-sel disease complicated with depression(r=0.606,0.798,0.672,all P<0.001).Serum LDH,MCP-1,and TCF4 were in-fluencing factors for depression in cerebral small vessel disease(P<0.05).The area under the receiver operating character-istic curve of LDH,MCP-1,and TCF4 in combination in the diagnosis of depression in cerebral small vessel disease was 0.917,which was superior to serum LDH,MCP-1,and TCF4 alone(ZLDH-combination=2.457,P=0.014;ZMCP-1-combination=2.384,P=0.017;ZTCF4-combination=2.317,P=0.021).Conclusion Serum LDH,MCP-1,and TCF4 levels increased in patients with cere-bral small vessel disease complicated with depression.Their combination is valuable in the diagnosis of cere-bral small vessel disease complicated with depression.