基于CiteSpace的脑卒中缺血再灌注损伤神经炎症反应可视化分析OA

Objective To systematically review the research status of neuroinflammation after stroke ischemia-reperfusion injury through bibliometric analysis,and to reveal the research hotspots,frontier trends and development trends in this field,so as to provide reference for subsequent research.Methods The literature on neuroinflammation after stroke ischemia-reperfusion injury in the Web of Science Core Collection(WoSCC)from January 2002 to December 2024 was retrieved.CiteSpace 6.1.R6 was used to visualize the number of publications,countries,authors,institutions,citations and keywords.Results A total of 662 related literatures were included,and the annual number of publications showed a significant upward trend.The results of the national cooperation network showed that China had the largest number of publications(463 literatures),and the centrality of the United States(0.87)and Japan(0.74)was higher.The results of institutional cooperation network showed that domestic comprehensive universities and medical universities dominate.The results of the author's cooperation network showed that a research team with Li Xing,Mao Meng,etc.as the core had been formed.Co-cited literature analysis showed that the role and mechanism of neuroinflammation in stroke ischemia/reperfusion injury and repair process had been widely concerned.Keyword analysis showed that oxidative stress,activation and inflammatory response were research hotspots,and microglia/macrophages and treatment strategies were future research trends.Conclusion The research on neuroinflammation after stroke ischemia-reperfusion injury has achieved certain results,but its mechanism still needs to be further explored to promote the development and clinical translation of anti-inflammatory drugs,enhance treatment efficiency,and improve patient outcomes.