电压门控钙通道在精神分裂症发病和治疗中的作用OA

Schizophrenia is a chronic mental disorder that causes psychotic symptoms by affecting early brain development,such as hallucinations,delusions and confusion,and motivational and cognitive dysfunc-tion.Voltage-gated calcium channels are crucial ion channels on the cell membrane,which can regulate calcium ion flow and participate in neuronal excitation and signal transmission and early brain development.Through various mechanisms,including modulation of neurotransmitter release,influence on synaptic plasticity,regula-tion of neuronal excitability and neural network activity,as well as effects on gene expression,Voltage-gated calcium channels play a vital role in maintaining and regulating cognitive functions.Voltage-gated calcium channels comprise multiple subunits and are categorized into high-voltage-activated and low-voltage-activated types.Polymorphisms and expression variations in related genes are associated with schizophrenia,while epi-genetic modifications such as methylation,histone modifications,and non-coding RNAs play significant roles in its pathogenesis.In the treatment of schizophrenia,more selective calcium channel blockers are regarded as a superior therapeutic strategy.This review aims to explore the role of voltage-gated calcium channels in the pathogenesis and treatment of schizophrenia and to provide ideas for the research of etiological mechanisms and treatment of schizophrenia.