维生素D在脓毒症中的作用及临床研究进展OA

Sepsis is a systemic inflammatory response syndrome caused by infection,and immune disor-ders play a key role in its pathogenesis.In recent years,studies have found that vitamin D not only regulates calcium and phosphorus metabolism,but also has obvious Immunomodulation and anti-infection functions.This article reviews the potential mechanisms of vitamin D in sepsis,including its regulation of innate and a-daptive immunity,anti-inflammatory and promotion of antimicrobial peptide expression,and protective effects on related organ damage.A number of clinical studies have shown that vitamin D deficiency is closely related to the severity and mortality of sepsis,and vitamin D supplementation may improve the prognosis of patients.