广西壮族自治区南宁地区去白细胞悬浮红细胞容量内控标准的界定与应用实践OA

Objective To establish the internal control range for the volume of leukoreduced suspended red blood cells(LRBC)prepared with fully automated systems in Nanning,Guangxi Zhuang Autonomous Re-gion and to evaluate its application in practice for ensuring blood safety.Methods A total of 10 009 bags of LRBC were randomly selected and weighed.The volume control ranges for each LRBC specification were cal-culated using both the"(-x)±2s"and"x±10%"methods.Additionally,a total of 4 533 LRBC bags were ran-domly selected for verification using the broader"(-x)±2s"standard,and units falling outside the limits under-went further quality testing.The influence of demographic factors,including gender,age,ethnicity,occupa-tion,and frequency of blood donations,on the volume range of 10 009 blood donors was analyzed.Results A total of 10 009 bags of LRBC were weighed,and the volume ranges determined by the"(-x)±2s"method were as follows:1.0 U∶111-142 mL,1.5 U∶180-227 mL,2.0 U∶252-318 mL.The ranges determined by the"(-x)±10%"method were:1.0 U∶114-139 mL,1.5 U∶183-224 mL,and 2.0 U∶256-314 mL.A total of 4 533 bags of LRBC were verified against the broader"(-x)±2s"range,with those within the range meeting re-quirements.Among the 27 bags outside the range,3 failed to meet quality standards.Demographic analysis re-vealed statistically significant differences(P<0.05)in the unit volume of LRBC among blood donors based on gender,age,occupation,and the number of blood donations.Conclusion The internal control standards for the volume range of LRBC in the blood center are established as follows:1.0 U∶111-142 mL,1.5 U∶180-227 mL,and 2.0 U∶252-318 mL.This standardization facilitates the timely detection of abnormal blood vol-umes during the blood preparation process,thereby ensuring the maintenance of blood quality.