蓝斑-去甲肾上腺素系统在注意中的作用机制OA

The locus coeruleus-norepinephrine(LC-NE)system is a critical neuromodulatory system in the brain,playing an essential role in attentional modulation.This article provides a systematic review of the mechanisms by which the LC-NE system contributes to attention,including:1)the firing patterns and activity dynamics of the LC-NE during attentional processes;2)behavioral and neurophysiological indicators that reliably reflect LC-NE activity;3)the role of LC-NE in the three attentional subsystems—alerting,orienting,and executive control;4)the associations between LC-NE function and various attention-related disorders.Future studies should integrate techniques such as pupillometry,event-related potentials,intracranial electroencephalography,high-resolution neuroimaging,and neuromodulation.Combining these high spatiotemporal resolution tracking with causal intervention approaches can further elucidate the dynamic regulatory mechanisms of the LC-NE in attentional processing,thereby providing a theoretical basis for interventions on attentional disorders.