免疫应答调控高血压炎症微环境的分子机制OA

Persistence of chronic low-grade inflammation is a key driver of hypertension.Molecular mechanisms such as complement molecules and inflammatory factor disorders damaging blood vessels,neuro-immune cell interactions,and immune response dysregulation aggravating target organ inflammation synergistically break the homeostasis of the inflammatory microenvironment of hypertension.The brain-gut axis mechanism is a new hotspot of hypertension inflammation.Gut microbiota affects the immune response in vivo through short-chain fatty acids(SCFAs)/trimethylamine oxide(TMAO),inducing inflammation and affecting blood pressure.In this article,by integrating the results of multi-dimensional research,new research,new progress and new targets in the direction of hypertension immunity were discussed,providing a new theoretical basis for in-depth understanding of the immunoregulation of hypertension.