不同中医证型2型糖尿病患者血尿酸水平与代谢相关脂肪性肝病的相关性研究OA

Objective:To investigate the correlation between serum uric acid(SUA)levels and metabolic dysfunction-associated fatty liver disease(MAFLD)in type 2 diabetic mellitus(T2DM)patients with different traditional Chinese medicine(TCM)syndrome types,providing a reference for the syndrome differentiation treatment of TCM.Methods:Clinical data of 200 cases of T2DM(48 cases of liver depression and spleen deficiency syndrome,50 cases of damp-heat accumulation syndrome,49 cases of qi and yin deficiency syndrome,and 53 cases of liver and kidney yin deficiency syndrome)combined with MAFLD were retrospectively analyzed.Levels of glycated hemoglobin(HbA1c),total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),alanine aminotransferase(ALT),aspartate aminotransferase(AST),SUA,creatinine(Cr)and SUA/Cr were compared.Multivariate logistic regression analysis was performed to analyze the influencing factors of different types of TCM.Results:There was no significant difference in gender ratio among the four syndrome types(P＞0.05),but significant differences were found in age,disease duration,and body mass index(BMI)(P＜0.05).There were no significant differences in TC and TG(P＞0.05),but significant differences were found in HDL-C and HbA1c(P＜0.05).In the pairwise comparison results,statistically significant differences in HDL-C and HbA1c values were found between the qi and yin deficiency syndrome group and the damp-heat accumulation syn-drome group,liver stagnation and spleen deficiency syndrome group and liver and kidney yin deficiency syndrome group,the liver and kidney yin deficiency syndrome group and the damp-heat accumulation syndrome group and the liver stagnation and spleen deficiency syndrome group,the damp-heat accumulation syndrome group and the liver stagnation and spleen defi-ciency syndrome group(P＜0.05).Multivariate logistic regression analysis showed that the age,disease duration,SUA/Cr,and BMI were common influencing factors for TCM syndrome differentiation in T2DM patients with MAFLD.SUA was a common influencing factor of damp-heat accumulation syndrome group and liver stagnation and spleen deficiency syndrome group.Cr was an influencing factor of damp-heat accumulation syndrome group and liver and kidney yin deficiency syn-drome group(P＜0.05).Conclusions:Age,disease duration,BMI,SUA,Cr,ALT,and SUA/Cr are influencing fac-tors for TCM syndrome differentiation in T2DM.Variations in these influencing factors can aid in syndrome differentiation(damp-heat accumulation syndrome,liver stagnation and spleen deficiency syndrome,qi and yin deficiency syndrome,and liver and kidney yin deficiency syndrome)and improve the diagnostic efficacy for T2DM patients.