冻融胚胎移植后患者腹痛对早期妊娠结局的影响OA

Objectives:To explore the effect of abdominal cramping following frozen embryo transfer(FET)on early pregnancy outcomes. Methods:This descriptive cross-sectional study included 226 patients who underwent FET at Northwest Women's & Children's Hospital between November and December 2024.Based on the presence of abdominal cramping after FET,patients were divided into a cramping group(n=132)and a non-cramping group(n=94).On the morning of serum β-HCG testing(prior to blood collection),participants completed an electronic questionnaire covering postoperative abdominal cramping,associated symptoms,concerns regarding pregnancy outcomes,demographic characteristics,and details of the treatment cycle.Multivariate logistic regression models were used to analyze the association between abdominal cramping and positive serum β-HCG outcomes. Results:Among 787 eligible FET patients,226(28.7％)completed the questionnaire and were recruited in the analysis.Of these,58.4％(132/226)reported abdominal cramping after FET.No significant difference was observed in the incidence of cramping between the serum β-HCG positive and negative groups(59.6％vs.54.2％,P=0.502).Patients reporting post-transfer cramping were more likely to have a history of dysmenorrhea(78.8％,104/132),nulliparity(59.8％,79/132),intraoperative cramping during the embryo transfer(38.6％,51/132),vaginal bleeding(20.5％,27/132),and particular concern about treatment outcomes(61.4％,81/132).The multivariate logistic regression analysis revealed that,after adjusting for confounders,cramping was not identified as an independent predictor for a positive serum β-hCG outcome[adjusted OR=1.5,95％CI(0.6,3.6),P=0.356]. Conclusions:Abdominal cramping was prevalent following FET and associated with certain clinical characteristics and particular concern about treatment outcomes.However,cramping was not significantly associated with the serum β-HCG positive rate in early pregnancy.