成纤维细胞生长因子21及闭锁小带蛋白1水平与急性冠脉综合征患者冠状动脉斑块稳定性、狭窄程度的关系OA

Objective To analyze the relationship between fibroblast growth factor 21(FGF21)and zonula occludens protein-1(ZO-1)and the plaque stability and stenosis degree of coronary artery in patients with acute coronary syndrome(ACS).Methods A retrospective analysis was conducted on 215 patients with ACS admitted to the 960th Hospital of the Joint Service Support Force of the Chinese People's Liberation Army from March 2022 to March 2025.General data,levels of FGF21 and ZO-1,plaque stability of coronary artery,and the stenosis degree of coronary artery were collected.Multivariate Logistic regression analysis was used to explore the influencing factors for the plaque stability and stenosis degree of coronary artery in patients with ACS.The ROC curve was employed to evaluate the predictive value of FGF21 and ZO-1 levels and their combination for unstable coronary artery plaque and severe stenosis of coronary artery in patients with ACS.Results Among the 215 ACS patients,60 had stable coronary plaques and 155 had unstable coronary plaques;116 had mild-to-moderate coronary plaque stenosis and 99 had severe coronary plaque stenosis.Multivariate Logistic regression analysis showed that diabetes,hyperlipidemia,TG,HDL-C,cardiac troponin T(cTnT),FGF21 level,and ZO-1 level were influencing factors for unstable coronary artery plaque in patients with ACS(P<0.05);family history of ACS,TG,HDL-C,cTnT,FGF21 level,and ZO-1 level were influencing factors for severe stenosis of coronary artery in patients with ACS(P<0.05).ROC curve analysis results showed that the AUC of FGF21 and ZO-1 levels and their combination in predicting unstable coronary artery plaque in patients with ACS was 0.829[95%CI(0.768-0.891)],0.755[95%CI(0.682-0.828)],0.871[95%CI(0.814-0.929)],respectively;the AUC of FGF21 and ZO-1 levels and their combination in predicting severe stenosis of coronary artery in patients with ACS was 0.802[95%CI(0.743-0.860)],0.794[95%CI(0.735-0.853)],0.874[95%CI(0.828-0.921)],respectively.Conclusion Elevated levels of FGF21 and ZO-1 are protective factors for unstable coronary artery plaque and severe stenosis of coronary artery in patients with ACS.Both of the two have certain predictive value for unstable coronary artery plaque and severe stenosis of coronary artery in patients with ACS,and their combination has higher predictive value.