基于骨钙素调控探讨中医药防治骨质疏松症研究进展与分子机制OA

Osteocalcin(OCN),as a specific secretory protein of osteoblasts,is not only a biomarker for diagnosing osteoporo-sis(OP),but its carboxylation-modulated"bone endocrine"effect also provides a new target for the treatment of metabolic bone diseases.This article retrieves relevant literature from databases such as PubMed and China National Knowledge Infrastruc-ture(CNKI)from January 2000 to April 2025,focusing on the"pathway activation-OCN expression-bone volume increase"phenotype,and concentrating on the molecular mechanism of traditional Chinese medicine regulating OCN expression to improve OP.The results show that the characteristics of multi-target regulation of OCN signaling network by traditional Chinese medicine are highly consistent with the complexity of OP pathology.However,most current experiments on OCN mainly focus on changes in expression levels,and the precise regulatory mechanism of its signaling pathway still needs to be deeply analyzed by combining metabolomics,organoid models,and other technologies.This article provides ideas and theoretical support for the research of pre-cise intervention of OP by traditional Chinese medicine through reviewing such literature.