运动干预对2型糖尿病患者颈动脉内膜中层厚度影响的Meta分析OA

Objective To evaluate the effects of different forms and intensities of exercise intervention on carotid intima-media thickness(CIMT)in patients with type 2 diabetes mellitus(T2DM).Methods Randomized controlled trials on the effects of exercise intervention on CIMT in T2DM patients were searched in PubMed,Cochrane Library,Web of Science,CNKI,Wanfang Data,VIP and CBMdisc from their establishment to January 10,2024.Two investigators independently performed literature screening,quality evaluation and data extraction.The meta-analysis was conducted using RevMan 5.4 and Stata 16.The sources of heterogeneity were identified through subgroup analysis and sensitivity analysis.Results A total of 7 articles were included,involving 680 subjects.Meta-analysis revealed that CIMT was significantly reduced in T2DM patients receiving exercise intervention compared to the control group[MD=-0.06,95％CI(-0.09,-0.04),P<0.05].Subgroup analysis revealed that CIMT was significantly reduced in both the aerobic exercise group[MD=-0.10,95％CI(-0.12,-0.09)]and the aerobic+resistance exercise group[MD=-0.06,95％CI(-0.08,-0.03)]compared to the control group(P<0.05 for both),with a more significant effect on CIMT reduction in the aerobic exercise group(χ2=11.02,P<0.05);additionally,CIMT was significantly reduced in both the≤12-week intervention group[MD=-0.10,95％CI(-0.12,-0.07)]and the 12-month intervention group[MD=-0.04,95％CI(-0.08,-0.01)]compared to the control group(P<0.05 for both),with a more significant effect on CIMT reduction in the≤12-week intervention group(χ2=5.95,P<0.05).Egger's test showed no significant publication bias(t=0.58,P>0.05).Conclusion Exercise intervention significantly reduces CIMT in T2DM patients,with a superior effect on CIMT reduction in aerobic exercise,especially moderate-intensity continuous exercise.