后叶加压素对焦虑的调节作用及其机制OA

The prevalence of anxiety disorders is rising,and the efficacy of existing treatments is limited.Arginine vasopressin(AVP),a neuropeptide,plays a crucial role in regulating emotions and social behaviors,particularly in the onset and modulation of anxiety,where it exhibits a complex bidirectional influence.This review explores the biological characteristics of A VP and its functions within the central nervous system,focusing on how A VP exerts bidirectional regulation on anxiety by modulating the hypothalamic-pitui-tary-adrenal(HPA)axis and influencing key neural circuits,such as the amygdala.Additionally,it summarizes the impact of different A VP sources,gender differences,social environment,and genetic factors on the relationship between A VP and anxiety.Research indi-cates that maintaining moderate A VP levels is essential for emotional balance,as excessive or insufficient A VP may exacerbate anxiety.Understanding the bidirectional mechanisms of A VP in anxiety regulation can shed light on the biological underpinnings of anxiety disor-ders,providing important insights for developing personalized treatment strategies.This review emphasizes the need for in-depth studies on the mechanisms of A VP receptors,taking individual differences into account to advance precision medicine and improve the effec-tiveness of anxiety.