经皮穴位电刺激联合柴胡加龙骨牡蛎汤治疗术后谵妄的效果观察OA

Objective To explore the effect of transcutaneous electrical acupoint stimulation(TEAS)combined with Chaihu Jia Longgu Muli Decoction(柴胡加龙骨牡蛎汤)in the treatment of postoperative delirium.Methods The patients who underwent e-lective abdominal surgery in Tangshan Hospital of Traditional Chinese Medicine from January 2021 to January 2024 were selected as the research subjects,and they were divided into combined group and control group by random number table method,with 43 cases in each group.The control group had no intervention measures during perioperative period,and the combined group was trea-ted with TEAS combined with Chaihu Jia Longgu Muli Decoction.The occurrence of postoperative delirium,surgery-related indi-cators,analgesia status[visual analogue scale(VAS)],sedation status[Richmond Agitation-Sedation Scale(RASS)],cognitive function[mini-mental state examination(MMSE)],serum indicators[interleukin-1β(IL-1β),neuron-specific enolase(NSE),central nervous specific protein(S100β)],sleep status[Pittsburgh sleep quality index(PSQI),sleep time,time to fall a-sleep,deep sleep time]were compared between groups.Results The incidence rate of postoperative delirium and confusion assess-ment method(CAM)score in the combined group were significantly lower than those in the control group(P＜0.05).The dosages of propofol and remifentanil in the combined group were significantly less than those in the control group(P＜0.05).At 1 h and 2 h after surgery,the VAS score was significantly risen than that at 30 min after surgery,and the score was lower in the combined group than that in the control group(P＜0.05).The RASS score of the patients was significantly declined compared with that at 30 min after surgery,and the combined group had lower score(P＜0.05).At 5 d after surgery,the MMSE score in the combined group was significantly higher than that in the control group(P＜0.05).The levels of IL-1 β,NSE and S100β in both groups were declined significantly,and the above levels in the combined group were lower than those in the control group(P＜0.05).The PSQI score and time to fall asleep of the patients at 3 days after surgery were significantly reduced than those before surgery,and the combined group had lower PSQI score and shorter time to fall asleep(P＜0.05).The sleep time and deep sleep time of the patients were significantly lengthened compared with those before surgery,and the two indicators in the combined group were lon-ger(P＜0.05).Conclusion TEAS combined with Chaihu Jia Longgu Muli Decoction can effectively reduce the incidence rate of postoperative delirium in the patients undergoing abdominal surgery.