急性缺血性脑卒中患者血清FGF20、ICAM3水平及与神经功能缺损程度的关系OA

Objective To investigate the relationship between serum fibroblast growth factor(FGF)20,in-tercellular adhesion molecule(ICAM)3 levels and neurological deficits in patients with acute ischemic stroke(AIS).Methods A total of 156 AIS patients admitted to the Second Medical Center of Chinese PLA General Hospital from January 2022 to August 2024 were prospectively selected as AIS group,which were divided into mild group,moderate group and severe group by National Institutes of Health Stroke Scale(NIHSS)score.Another 78 healthy volunteers who came to the the Second Medical Center of Chinese PLA General Hospital for physical examination during the same period were selected as the control group.Baseline data of AIS pa-tients were collected.The levels of serum FGF20 and ICAM3 in each group were detected by enzyme-linked immunosorbent assay.Spearman correlation analysis was used to analyze the correlation between serum FGF20 and ICAM3 levels and the degree of neurological deficits in AIS patients.The influencing factors of neurological deficits in AIS patients were analyzed by ordinal multivariate Logistic regression analysis.The re-ceiver operating characteristic(ROC)curve was drawn to evaluate the diagnostic value of serum FGF20 and ICAM3 for moderate to severe neurological deficits and severe neurological deficits in AIS patients.Results Compared with the control group,the serum FGF20 level in the AIS group decreased,and the ICAM3 level in-creased,with statistically significant differences(P<0.05).NIHSS score results showed that among the 156 AIS patients,there were 47 cases in the severe group,55 cases in the moderate group and 54 cases in the mild group.The age and cerebral infarction volume in the moderate group and the severe group were larger than those in the mild group,the serum ICAM3 level was higher than that in the mild group,and the serum FGF20 level was lower than that in the mild group,the differences were statistically significant(P<0.05).The age and cerebral infarction volume of the severe group were larger than those in the moderate group,the serum ICAM3 level was higher than that in the moderate group,and the serum FGF20 level was lower than that in the moderate group,the differences were statistically significant(P<0.05).Spearman correlation analysis showed that the degree of neurological deficit in AIS patients was negatively correlated with serum FGF20 level(rs=-0.759,P<0.001)and positively correlated with ICAM3 level(rs=0.747,P<0.001).Ordinal multivariate Logistic regression analysis showed that elevated serum ICAM3 level was an independent risk factor for the aggravation of neurological deficit in AIS patients(P<0.05),and elevated serum FGF20 level was an independent protective factor for the aggravation of neurological deficit in AIS patients(P<0.05).ROC curve analysis showed that the AUC of combined serum FGF20 and ICAM3 in predicting moderate to severe neurological deficits in AIS patients was 0.877,which was greater than 0.811 and 0.803 predicted by serum FGF20 and ICAM3 alone(Z=2.675,P=0.008;Z=2.572,P=0.010);the AUC of combined serum FGF20 and ICAM3 in predicting severe neurological deficits in AIS patients was 0.923,which was greater than 0.830 and 0.824 predicted by serum FGF20 and ICAM3 alone(Z=3.209,P=0.001;Z=3.457,P=0.001).Conclusion The decrease of serum FGF20 level and the increase of serum ICAM3 level are closely re-lated to the aggravation of neurological deficit in AIS patients,and the combined detection of the two indica-tors has a good predictive value for the aggravation of neurological deficit in AIS patients.