脑小血管病患者血清LRG1、HDAC3、ZO-1水平与认知功能障碍的关系OA

Objective To investigate the relationship between serum leucine rich alpha-2 glycoprotein-1(LRG1),histone deacetylase 3(HDAC3),zonula occluden-1(ZO-1)levels and cognitive impairment(CI)in patients with cerebral small vessel disease(CSVD).Methods A total of 90 patients with CSVD admitted to the hospital from November 2023 to November 2024 were enrolled in the CSVD group.According to the scores of the Montreal Cognitive Assessment,they were divided into functional impairment group(n=41)and normal function group(n=49).Additionally,90 healthy individuals who underwent physical examinations at the hospital during the same period were selected as control group.Enzyme-linked immunosorbent assay(ELISA)method was used to detect serum LRG1,HDAC3 and ZO-1 levels.Multivariate Logistic regression analysis was used to identify factors influencing the occurrence of CI in patients with CSVD.Receiver operat-ing characteristic(ROC)curves were performed to discuss the diagnostic value of serum LRG1,HDAC3 and ZO-1 for CI in patients with CSVD.Results Compared with the control group,the serum LRG1 and HDAC3 levels in the CSVD group were higher(P<0.05),while the serum ZO-1 level in the CSVD group was lower(P<0.05).Compared with the normal function group,the levels of serum TG,LRG1 and HDAC3 in the functional impairment group were higher(P<0.05),and serum ZO-1 level in the functional impairment group was lower(P<0.05).The results of multivariate Logistic regression analysis showed that elevated ser-um levels of LRG1 and HDAC3 were independent risk factors for CI in CSVD patients(P<0.05),while ele-vated serum level of ZO-1 was an independent protective factor for CI in CSVD patients(P<0.05).ROC curve analysis results showed that the area under the curve(AUC)for serum LRG1,HDAC3 and ZO-1 indi-vidually diagnosing CI in CSVD patients were 0.818,0.808 and 0.827,respectively,while the AUC for their combined diagnosis was 0.943,which was superior to the AUCs of the individual indicators(ZLRG-joint=2.779,ZHDAC3-joint=3.068,ZZO-1-joint=2.480,all P<0.05).Conclusion In CSVD patients,serum levels of LRG1 and HDAC3 are elevated,while serum level of ZO-1 is decreased.The above three factors are all influencing factor for the occurrence of CI in CSVD patients,and their combined detection has high diagnostic value for CI.