冠心病患者血清HMGA2和IGFBP2水平及对PCI术后支架内再狭窄的预测价值OA

Objective To analyze the predictive value of serum high-mobility group protein A2(HMGA2)and insulin-like growth factor-binding protein 2(IGFBP2)levels for in-stent restenosis(ISR)in coronary heart disease patients after percutaneous coronary intervention(PCI)by detecting the serum levels of HM-GA2 and IGFBP2.Methods A total of 294 coronary heart disease patients who underwent PCI in this hospital from July 2019 to July 2023 were selected as the research subjects.According to the results of coronary angi-ography after 1-year follow-up,they were divided into the ISR group and the non-ISR group;they were also di-vided into the mild group,the moderate group and the severe group using the Gensini scoring method.The baseline data of the patients were collected.The serum levels of HMGA2 and IGFBP2 in all patients were de-tected by enzyme-linked immunosorbent assay.Multivariate Logistic regression analysis was used to analyze the influencing factors of ISR after PCI.The receiver operating characteristic(ROC)curve was drawn to ana-lyze the predictive value of serum HMGA2 and IGFBP2 for ISR after PCI.Results There were 50 cases in the ISR group and 244 cases in the non-ISR group.The proportion of patients with diabetes mellitus,and the ser-um levels of HMGA2,IGFBP2 and brain natriuretic peptide(BNP)in the ISR group were higher than those in the non-ISR group,and the stent length was longer than that in the non-ISR group,with statistically signifi-cant differences(P<0.05).There were 27 cases in the mild group,14 cases in the moderate group,and 9 ca-ses in the severe group.The serum levels of HMGA2 and IGFBP2 in the severe group were significantly high-er than those in the mild and moderate groups(P<0.05),and the serum levels of HMGA2 and IGFBP2 in the moderate group were significantly higher than those in the mild group(P<0.05).The results of multiva-riate Logistic regression analysis showed that co-existing diabetes mellitus,increased stent length,and in-creased serum levels of BNP,HMGA2 and IGFBP2 were all risk factors for ISR after PCI in coronary heart disease patients(P<0.05).The results of ROC curve analysis showed that the areas under the curve(AUC)of serum HMGA2,IGFBP2 alone and in combination in predicting ISR after PCI in coronary heart disease pa-tients were 0.887,0.854 and 0.935,respectively.The AUC of the combined prediction of serum HMGA2 and IGFBP2 was significantly greater than that of serum HMGA2(Z=2.128,P=0.033)and IGFBP2(Z=3.323,P=0.001)alone.Conclusion The serum levels of HMGA2 and IGFBP2 are increased in coronary heart disease patients with ISR after PCI,and serum HMGA2 and IGFBP2 have a certain predictive value for ISR after PCI in patients with coronary heart disease.