冠心病患者血清IL-5、GPX4水平与心功能的相关性OA

Objective To explore the correlation between the levels of serum interleukin-5(IL-5),glutathi-one peroxidase-4(GPX4)and cardiac function in patients with coronary atherosclerotic heart disease(CHD).Methods A total of 126 patients with CHD who were admitted to Dongcheng District First People's Hospital from October 2021 to October 2022 were prospective selected as the disease group.Among them,there were 36 cases of grade Ⅱ,62 cases of grade Ⅲ and 28 cases of grade Ⅳ according to the New York Heart Associa-tion(NYHA)classification.Another 120 healthy individuals who underwent physical examinations at the Dongcheng District First People's Hospital during the same period were selected as the control group.Baseline data of CHD patients were collected.The levels of IL-5,GPX4,brain natriuretic peptide(BNP)and creatine kinase isoenzyme(CK-MB)in the serum of each group were detected by enzyme-linked immunosorbent as-say.The left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVESD),left ven-tricular end-diastolic diameter(LVEDD),cardiac output(CO),interventricular septum thickness(IVS),and left ventricular mass(LV mass)of patients with CHD were diagnosed by color Doppler ultrasound.Pearson correlation analysis was applied to analyze the correlation between serum IL-5,GPX4 and cardiac function in-dicators in CHD patients.Results The systolic blood pressure and low-density lipoprotein cholesterol(LDL-C)level in the disease group were significantly higher than those in the control group,while the serum levels of IL-5,GPX4 and high-density lipoprotein cholesterol(HDL-C)were significantly lower than those in the control group,and the differences were all statistically significant(P<0.05).The LVESD,LVEDD,LV mass,IVS in the disease group were obviously larger than those in the control group,and serum BNP,CK-MB levels were significantly higher than those in the control group,while LVEF and CO were significantly lower than those in the control group,and the differences were all statistically significant(P<0.05).The LVEF,CO and serum levels of IL-5 and GPX4 in NYHA class Ⅳ CHD patients were significantly lower than those in patients with NYHA class Ⅲ and Ⅱ,moreover,the LVEF,CO and serum levels of IL-5 and GPX4 in patients with NYHA class Ⅲ were significantly lower than those in patients with NYHA class Ⅱ,and the differences were statistically significant(P<0.05).The LVESD,LVEDD,LV mass,IVS of patients with NYHA class Ⅳwere obviously larger than those of patients with classes Ⅲ and Ⅱ,serum BNP and CK-MB levels were signif-icantly higher than those of patients with classes Ⅲ and Ⅱ,with statistically significant differences(P<0.05);moreover,the LVESD,LVEDD,LV mass,IVS of patients with class Ⅲ CHD were larger than those of patients with class Ⅱ,and serum BNP,CK-MB levels were significantly higher than those of patients with class Ⅱ,with statistically significant differences(P<0.05).The results of Pearson correlation analysis showed that the levels of serum IL-5 and GPX4 in patients with CHD were negatively correlated with serum BNP,CK-MB levels,LVESD,LVEDD,LV mass and IVS(P<0.05),and positively correlated with LVEF and CO(P<0.05).Conclusion The expression levels of IL-5 and GPX4 in the serum of CHD patients are promi-nently reduced,and they are closely related to cardiac function indicators.