致人体健康危害的饮用水氯化消毒副产物流行病学调查研究进展OA

[Objective]Chlorinated disinfection byproducts(Cl-DBPs)generated during the chlorination of drinking water pose potential environmental and health risks.This paper reviews the progress of epidemiological studies on Cl-DBPs in drinking water that are harmful to human health,provides a summary and outlook,thereby offering scientific basis for drinking water quality management and public health security.[Methods]This paper examines the association between Cl-DBPs and human malignancies such as bladder cancer and colorectal cancer.It synthesizes research progress on the health hazards of key Cl-DBPs in water quality standards,integrating their impacts on reproductive hormone disruption,adverse pregnancy outcomes,and fetal growth restriction.It examines the formulation and revision context of relevant limits in China's new national drinking water standards,explores the correlation between these health effects and potential mechanisms,and aims to provide references for advancing drinking water quality management and guaranteeing public health.[Results]Long-term exposure to Cl-DBPs in drinking water is statistically associated with multiple health outcomes.These include significant impacts on bladder cancer,colorectal cancer,reproductive health,and fetal growth and development.Future studies should conduct a global systematic survey of Cl-DBPs in drinking water to reveal their worldwide distribution patterns and its driving factors.This would enable the scientific identification of high-risk areas and susceptible populations,thereby improving drinking water quality.[Conclusion]Cl-DBPs pose potential hazards to multiple human body systems,with particular concern about their carcinogenicity and impact on reproductive development.Standard for Drinking Water Quality(GB 5749-2022)in China has strengthened controls on Cl-DBPs.Future efforts should focus on conducting global systematic surveys,internal exposure assessments,and multi-route exposure studies to more accurately evaluate the associated health risks.