前循环急性大血管闭塞性卒中患者术前CTA参数NLR及S100β变化与血管内取栓预后的关系OA

Objective To analyze the changes of preoperative CT angiography(CTA)parameters,neutrophil-to-lymphocyte ratio(NLR)and S100 calcium-binding protein(S100β)in patients with anterior circulation acute ischemic stroke with large vessel occlusion(AIS-LVO)and their relationship with the prognosis of endovascular thrombectomy.Methods Adopting a retrospective analysis design,100 patients with AIS-LVO admitted to the Second Affiliated Hospital of Bengbu Medical University from February 2022 to August 2024 were selected as observation group,and 50 patients with non-large vascular occlusion during the same period were collected as control group.Serum S100β,NLR and CTA parameters(collateral circulation score,clot burden score(CBS))were compared between the two groups.The differences in clinical data of patients with different prognosis in the observation group were analyzed.Binary Logistic regression analysis was used to analyze the relationship between the above indicators and prognosis,and ROC curve was drawn to analyze the predictive value.Results Serum S100β level,NLR and collateral circulation score in the observation group were higher than those in the control group(P＜0.05),while the CBS score was lower than that in the control group(P＜0.05).The time from onset to recanalization in the poor prognosis group was longer than that in the good prognosis group(P＜0.05),and serum S100β level and NLR were higher than those in the good prognosis group(P＜0.05),while the collateral circulation score and CBS score were lower than those in the good prognosis group(P＜0.05).Logistic regression analysis showed that increased serum S100β level and NLR,decreased collateral circulation score and CBS score were independent risk factors for poor prognosis in AIS-LVO patients after endovascular thrombectomy(P＜0.05).ROC curve analysis showed that serum S100β,NLR,collateral circulation score and CBS score had good predictive efficiency on poor prognosis of AIS-LVO patients after endovascular thrombectomy,and the area under the curves(AUCs)were 0.873,0.890,0.752 and 0.858,respectively,and the best cut-off values were 0.92 μg/L,5.84,3 points and 6 points,respectively.Conclusion Preoperative increased serum S100β level and NLR and decreased collateral circulation score and CBS score in AIS-LVO patients are risk factors for poor prognosis after endovascular thrombectomy,and have good predictive value on poor prognosis.