富血小板血浆注射联合背根神经节脉冲射频治疗带状疱疹后神经痛的疗效OA

Objective To observe the clinical efficacy of platelet-rich plasma(PRP)injection combined with dorsal root ganglion pulsed radiofrequency(DRG-PRF)in the treatment of postherpetic neuralgia(PHN).Methods The clinical data of patients with PHN who received DRG-PRF in the First Affiliated Hospital of Chengdu Medical College from March 2023 to January 2024 were retrospectively analyzed.According to whether PRP treatment was performed or not,they were divided into observation group(46 cases,PRP combined with DRG-PRF)and control group(52 cases,DRG-PRF).The levels of inflammatory factors(C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)),pain-causing factors(prostaglandinE2(PGE2),monocyte chemotactic protein-1(MCP-1))and pain stress hormones(norepinephrine(NE),epinephrine(E),cortisol(COR))before treatment and after 1 month of treatment and pain degree(visual analogue scale(VAS))before treatment and after 2 weeks and 1 month of treatment the were compared between the both groups.Results After 1 month of treatment,the levels of CRP,IL-6,TNF-α,PGE2,MCP-1,NE,E and COR(3.56±0.52,8.59±0.71,19.40±2.16,118.25±17.32,52.10±6.13,387.17±72.50,56.49±6.19,and 103.45±18.62,respectively)in the observation group were significantly lower than those in the control group(4.73±0.71,12.45±1.26,21.52±3.13,213.55±40.31,76.31±13.14,436.78±83.62,66.12±8.14,and 118.17±20.04,respectively,P＜0.05).The VAS scores in the observation group(3.01±0.48 and 2.43±0.28)after 2 weeks and 1 month of treatment were significantly lower than those in the control group(3.68±0.61 and 3.17±0.64,P＜0.05).Conclusion PRP combined with DRG-PRF can significantly inhibit the productions of inflammation and pain-causing factors in patients with PHN,relieve the stress response and alleviate the pain,with good clinical efficacy.