中医药靶向调控线粒体质量控制系统治疗脑缺血再灌注损伤研究进展OA

Cerebral ischemia-reperfusion injury(CIRI)is defined as secondary pathological damage that may be triggered when blood perfusion is restored to brain tissue after ischemia.Mitochondria are the"energy powerhouse"of the cell,with impor-tant physiological functions such as supplying energy,metabolizing reactive oxygen species,storing calcium,and mediating pro-grammed cell death.Maintaining mitochondrial homeostasis is therefore decisive for the survival and functional recovery of nerve cells.In contrast,the mitochondrial quality control(MQC)can attenuate CIRI-induced mitochondrial structural and functional damage by regulating the processes of mitochondrial dynamics,mitochondrial autophagy,mitochondrial biogenesis,and mitochon-drial translocation.In recent years,TCM therapies have been more widely applied,which can significantly improve CIRI through multiple pathways,targets and levels.Therefore,a review on the mechanism of MQC in CIRI and the research progress of TCM in CIRI by modulating MQC is conducted to provide new ideas and research directions for the treatment of CIRI in the future.