MAPK信号通路在白念珠菌药物耐受与宿主互作中的双向调控机制OA

Candida albicans is a common opportunistic pathogen fungus in humans.The inva-sive infection it causes have a high mortality rate,posing significant challenges for clinical preven-tion and treatment.The graving problem of drug resistance is one of the primary causes for treatment failure,making it urgent to elucidate its drug resistance mechanisms and identify new drug tar-gets.This article reviews the bidirectional regulatory mechanism of the MAPK signaling pathway in Candida albicans drug tolerance and host interaction:On one hand,it reveals how the MAPK sig-naling pathway mediates interactions between Candida albicans and its host,such as through im-mune evasion and inflammatory responses;On the other hand,it elucidates the MAPK-mediated resistance mechanisms in Candida albicans,including cell wall synthesis and remodeling,hyphal formation,oxidative stress,and biofilm formation,along with recent advances in drug re-search.This aims to provide new insights into understanding the pathogenicity and resistance of Can-dida albicans and to offer theoretical support for developing novel antifungal strategies targeting the MAPK pathway.