超声心动图冠状动脉Z值与川崎病患儿心率、炎症指标和血液成分指标的相关性分析OA
Correlation analysis of echocardiographic coronary artery Z-score with heart rate,inflammatory markers,and blood component indices in children with Kawasaki disease
目的 分析超声心动图冠状动脉Z值与川崎病患儿心率、炎症指标和血液成分指标的相关性.方法 以陕西省人民医院2022年3月～2025年3月收治的233例川崎病患儿为研究对象,采用超声心动图检查测量患者6个段的内径,包括左冠状动脉主干(LMCA)、左前降支(LAD)、左回旋支(LCX)、右冠状动脉(RCA)近段、RCA中段、RCA远段,计算不同分支内径的Z值,取最大Z值作为该患儿的Z值评价依据.根据Z值将患儿分为扩张(2≤Z值<2.5)、小冠脉瘤(2.5≤Z值<5)和中-巨大冠脉瘤(Z值≥5)组.统计各组患儿的一般资料[性别、年龄、身高、体质量、体表面积(BSA)、心率、发热时间],检测患儿的生化指标[血小板(PLT)、C反应蛋白(CRP)、白细胞计数(WBC)、血沉(ESR)、红细胞计数(RBC)、中性粒细胞比例(NE%)、白蛋白(ALB)、血红蛋白(HGB)]水平.分析患儿一般资料和生化指标与Z值的相关性并进行多元线性回归分析,筛选出影响Z值的独立危险因素.结果 与扩张组和小冠脉瘤组相比,中-巨大冠脉瘤组患儿的PLT、CRP、WBC、ESR和NE%水平升高(P<0.05),RBC、ALB和HGB水平降低(P<0.05).Z值与心率、PLT、CRP、WBC、ESR和NE%水平呈正相关(P<0.05),与RBC、ALB和HGB水平呈负相关(P<0.05).多元线性回归分析结果表明CRP(β=0.464)、ESR(β=0.198)、NE%(β=0.163)和ALB(β=-0.103)对Z值具有显著影响(P<0.001).结论 CRP、ESR、NE%和ALB对Z值具有独立预测作用,是评估川崎病冠状动脉病变严重程度及扩张程度的预测指标.
Objective To analyze the correlation between coronary artery Z-scores measured by echocardiography and heart rate,inflammatory indicators,and blood component indices in children with Kawasaki disease.Methods A total of 233 children with Kawasaki disease admitted to Shaanxi Provincial People's Hospital from March 2022 to March 2025 were enrolled as research subjects.Echocardiography was performed to measure the internal diameters of 6 coronary artery segments,including the left main coronary artery(LMCA),left anterior descending artery(LAD),left circumflex artery(LCX),proximal right coronary artery(RCA),middle RCA,and distal RCA.Z-scores for each vessel segment were calculated,and the maximum Z-score was used as the evaluation index for each child.According to the Z-scores,the children were divided into three groups:Dilatation group(2≤Z-score<2.5),Small coronary aneurysm group(2.5≤Z-score<5),and Medium-large coronary aneurysm group(Z-score≥5).General data of children in each group[gender,age,height,weight,body surface area(BSA),heart rate,fever duration]were collected,and the levels of biochemical indicators[platelets(PLT),C-reactive protein(CRP),white blood cell count(WBC),erythrocyte sedimentation rate(ESR),red blood cell count(RBC),neutrophil percentage(NE%),albumin(ALB),hemoglobin(HGB)]were detected.Correlations between general data,biochemical indicators and Z-scores were analyzed,and multiple linear regression analysis was performed to screen for independent risk factors affecting Z-scores.Results Compared with the Dilatation group and Small coronary aneurysm group,the Medium-large coronary aneurysm group had significantly higher levels of PLT,CRP,WBC,ESR,and NE%(P<0.05),and significantly lower levels of RBC,ALB,and HGB(P<0.05).Z-scores were positively correlated with heart rate,PLT,CRP,WBC,ESR,and NE%(P<0.05),and negatively correlated with RBC,ALB,and HGB(P<0.05).Multiple linear regression analysis showed that CRP(β=0.464),ESR(β=0.198),NE%(β=0.163),and ALB(β=-0.103)had a significant impact on Z-scores(P<0.001).Conclusion CRP,ESR,NE%,and ALB have independent predictive effects on coronary artery Z-scores,and can serve as predictive indicators for evaluating the severity and degree of dilation of coronary artery lesions in children with Kawasaki disease.
严晓华;张泰鸣;高娜;穆志龙;贺望;万萱;孙亚男;马娟
陕西省人民医院儿童病院,陕西 西安 710068新疆医科大学儿科学院,新疆 乌鲁木齐 830054陕西省人民医院儿童病院,陕西 西安 710068陕西省人民医院儿童病院,陕西 西安 710068陕西省人民医院儿童病院,陕西 西安 710068陕西省人民医院儿童病院,陕西 西安 710068陕西省人民医院儿童病院,陕西 西安 710068陕西省人民医院检验科,陕西 西安 710068
川崎病超声心动图冠状动脉Z值诊断炎症血液成分
Kawasaki diseaseechocardiographycoronary artery Z-scorediagnosisinflammationblood components
《分子影像学杂志》 2026 (1)
7-14,8
陕西省中医药管理局科研课题(2021-01-ZZ-014)陕西省中西医结合心血管病防治重点实验室开放课题(2022XXG-YB-003)陕西省人民医院科技人才项目(拔尖人才)(2022BJ-08)
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