真菌组蛋白H3K4 甲基化在植物与真菌互作中的作用OA

Histone H3K4 methylation(H3K4me)is one of the core mechanisms of epigenetic regulation.It dynamically modifies chromatin structure and is widely involved in the interaction between fungi and plants.This paper reviewed the molecular mechanisms of H3K4 methylation,including the dynamic equilibrium network mediated by KMT2 family transmethylase and JmjC/LSD demethylases.It also focused on the effects of H3K4 methylation on fungal growth and development,secondary metabolites production,pathogenicity,and environmental adaptability through fungal gene expression regulation.Future research needs to further elucidate the functions of H3K4 methylation in plant symbiotic fungi and explore its synergistic regulatory networks with other epigenetic modifications,which will provide a theoretical basis for the development of epigenetic-targeted disease control strategies and the exploitation of fungal secondary metabolites.