祛痰活血法结合西药治疗糖尿病周围神经病变(痰湿阻络证)的作用研究OA
Study on the Effect of Phlegm Elimination and Blood Circulation Promotion Method Combined with Western Medicine in Treating Diabetic Peripheral Neuropathy of Phlegm-Dampness Obstructing Collateral Type
目的:探讨祛痰活血法结合西药治疗糖尿病周围神经病变(DPN)痰湿阻络证的作用.方法:选择2021 年1 月—2023 年11 月许昌市人民医院收治的92 例DPN痰湿阻络证患者作为研究对象,并将其按照随机数字表分为联合组和对照组,每组 46 例.本研究中联合组脱落/剔除 3 例(2 例自行退出,1 例未按研究要求服药),对照组脱落/剔除4 例(1 例自行退出,2 例未按研究要求服药,1 例病情加重,需采取其他治疗方案),最终联合组纳入43 例患者,对照组纳入42 例患者.对照组采用西药治疗,联合组在此基础上增加祛痰活血法治疗.比较两组治疗前后的神经功能、神经传导速度、中医症状积分及氧化应激指标,同时比较两组临床疗效及用药安全性.结果:两组治疗后的丙二醛(MDA)、多伦多临床评分系统(TCSS)得分、中医症状积分均降低(P<0.05,P<0.01),且联合组更低(P<0.05,P<0.01).两组治疗后的超氧化物歧化酶(SOD)、还原性谷胱甘肽(GSH)及神经传导速度均升高(P<0.05),且联合组更高(P<0.05).联合组总有效率高于对照组(P<0.05).两组不良反应发生率无明显差异(P>0.05).结论:祛痰活血法结合西药治疗DPN痰湿阻络证能有效改善患者中医症状、增强神经功能、减轻氧化应激,且临床疗效显著、不良反应的发生风险低.
Objective:To investigate the effect of eliminating phlegm and promoting blood circulation method combined with Western medicine in treating diabetic peripheral neuropathy(DPN)with the pattern of phlegm-dampness obstructing collaterals.Methods:A total of 92 DPN patients with the pattern of phlegm-dampness obstructing collaterals admitted to Xuchang People's Hospital from January 2021 to November 2023 were selected as study subjects and divided into a combination group and a control group according to a random number table,with 46 cases in each group.In this study,3 cases in the combination group dropped out/were excluded(2 withdrew voluntarily,1 did not take medication as required by the study),and 4 cases in the control group dropped out/were excluded(1 withdrew voluntarily,2 did not take medication as required by the study,1 had worsened condition requiring other treatment plans).Finally,43 patients were included in the combination group and 42 in the control group.The control group was treated with Western medicine,while the combination group was additionally treated with the method of eliminating phlegm and promoting blood circulation.Neurological function,nerve conduction velocity,traditional Chinese medicine(TCM)symptom scores,and oxidative stress indicators were compared between the two groups before and after treatment.Clinical efficacy and medication safety were also compared between the two groups.Results:After treatment,malondialdehyde(MDA),Toronto Clinical Scoring System(TCSS)scores,and TCM symptom scores decreased in both groups(P<0.05,P<0.01),and the combination group was lower(P<0.05,P<0.01).Superoxide dismutase(SOD),reduced glutathione(GSH),and nerve conduction velocity increased in both groups after treatment(P<0.05),and the combination group was higher(P<0.05).The total effective rate in the combination group was higher than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The method of eliminating phlegm and promoting blood circulation combined with Western medicine can effectively improve TCM symptoms,enhance neurological function,reduce oxidative stress,and demonstrate significant clinical efficacy with a low risk of adverse reactions in treating DPN with the pattern of phlegm-dampness obstructing collaterals.
段凯敏;冀璐;杨俊朋
许昌市人民医院内分泌代谢科,河南 许昌 461000许昌市人民医院内分泌代谢科,河南 许昌 461000河南省人民医院内分泌科,河南 郑州 450003
医药卫生
祛痰活血法糖尿病周围神经病变痰湿阻络证
Eliminating phlegm and promoting blood circulation methodDiabetic peripheral neuropathyPattern of phlegm-dampness obstructing collaterals
《中医药学报》 2026 (2)
93-97,5
河南省中医药科学研究专项课题(20-21ZY2304)
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