黄连-吴茱萸自组装体性质形态及其形成对7种成分的影响OA

Objective:To investigate the properties and morphology of Coptis chinensis-Evodia rutaecarpa self-assemblies and their effects on the contents of seven components:epiberberine hydrochloride,coptisine hydrochloride,palmatine hydrochloride,berberine hydrochloride,evodiamine,rutaecarpine,and evodin.Methods:The morphology,fluidity,and water absorption rate of the self-assemblies were characterized.High-performance liquid chromatography(HPLC)was used to compare the differences in the seven components among single decoctions of Coptis chinensis and Evodia rutaecarpa,co-decoction supernatant,and the self-assemblies.Results:The self-assemblies exhibited good fluidity and water-absorbing swelling properties.Scanning electron microscopy revealed that they were spherical particle aggregates.The formation of self-assemblies led to a decrease in the contents of the seven components in the supernatant,with significant reductions in evodiamine,berberine hydrochloride,and evodin,while epiberberine hydrochloride slightly increased.Among the seven components in the self-assemblies,berberine hydrochloride was relatively abundant and likely a key component in the formation of the self-assemblies.Conclusion:A quantitative method for the seven components in Coptis chinensis-Evodia rutaecarpa self-assemblies was established,which can be used by enterprises to monitor changes in the main components in the self-assemblies and supernatant.The Coptis chinensis-Evodia rutaecarpa self-assemblies are fundamentally different from chemical precipitation and can serve as a green strategy for supramolecular design and construction.This provides insights into the reuse of carrier-free self-assembled drugs and offers a new perspective for understanding self-assembly phenomena in traditional Chinese medicine decoctions.