真菌Ndt80-like蛋白研究进展OA

To gain a comprehensive understanding of Ndt80-like protein functions and explore their potential as targets for antifungal drug development,a systematic literature search was conducted in this study by taking the keywords"Ndt80""Ndt80-like protein"and"fungi".The structure of Ndt80-like proteins and their roles in sexual reproduction,meiosis,environmental nutrient sensing,and cellular metabolic remodeling were summarized.The feasibility of developing antifungal drugs targeting these proteins was assessed.The results show that:1)The DNA-binding domains of Ndt80-like proteins are highly conserved in both Ascomycetes and Basidiomycetes,while their activation domains are highly variable.2)Ndt80-like proteins are the key transcriptional activators that regulate sexual reproduction and meiosis in fungi.3)These proteins integrate multiple nutrient signals to modulate fungal development and environmental adaptation.In summary,the fungal Ndt80-like proteins,as members of the p53-like superfamily of transcription factors,play a central role in regulating fungal sexual reproduction,growth and development,metabolic remodeling,environmental stress responses,and pathogenicity.They hold significant application potential for fungal disease control and the development of highly efficient industrial chassis strains.