异甘草酸镁联合奥曲肽在急性重症胰腺炎中的应用效果OA

Objective:To analyze the application effect of Magnesium Isoglycyrrhizinate combined with Octreotide in acute severe pancreatitis.Method:A total of 80 patients with acute severe pancreatitis from Ji'an Central People's Hospital from February 2022 to June 2024 were selected and divided into two groups according to the random number table method.Both groups used routine treatment,the control group(40 cases)was treated with Octreotide in addition,and the study group(40 cases)was treated with Magnesium Isoglycyrrhizinate on the basis of the control group.Both groups were treated continuously for 14 days.The clinical efficacy,intestinal mucosal barrier function,disease severity,inflammatory factor levels and immunoglobulin levels of the two groups were compared.Result:After treatment,the levels of TNF-α,IL-6,diamine oxidase(DAO),D-lactic acid,and endotoxin(ET)in the study group were lower than those in the control group,while the levels of IL-10,IgG,and total effective rate were higher than those in the control group(P<0.05).The acute physiology and chronic health evaluation Ⅱ(APACHEⅡ)scores of the study group at 3,7,and 14 days after treatment were lower than those of the control group(P<0.05).Conclusion:Magnesium Isoglycyrrhizinate combined with Octreotide can reduce the levels of inflammatory factors and disease severity in patients,and improve the immune function and intestinal mucosal barrier function of patients.