标准化口腔护理干预对头颈部肿瘤同步放化疗患者口腔黏膜炎的影响OA
Influence of Standardized Oral Care Intervention on Oral Mucositis in Patients with Head and Neck Tumors Undergoing Concurrent Chemoradiotherapy
目的:探讨标准化口腔护理方案对头颈部肿瘤同步放化疗患者口腔黏膜炎的影响.方法:本研究采用前瞻性研究方法,将广西壮族自治区人民医院桃源院区2023年7月—2024年7月收治的100例接受同步放化疗的头颈部肿瘤患者按随机数字表法分为对照组(n=50)和干预组(n=50).两组患者均进行 5～6 周的同步放化疗,期间给予相应护理措施.对照组行常规护理,干预组在常规护理的基础上实施标准化口腔护理干预.对比两组口腔黏膜炎发生率及严重程度(WHO口腔黏膜炎分级标准);以数字分级评分法(NRS)评估两组口腔疼痛程度;以生活质量测定量表(QLQ-C30)评估两组生活质量;评估两组炎症指标水平.结果:干预组口腔黏膜炎发生率及严重程度显著低于对照组(P<0.05).同步放化疗3 周、结束后,干预组NRS评分低于对照组(P<0.05).同步放化疗结束后,干预组QLQ-C30 中功能评分高于对照组,症状评分低于对照组(P<0.05).同步放化疗 3 周、结束后,干预组IL-10 低于对照组,IL-12 高于对照组(P<0.05).结论:标准化口腔护理干预对头颈部肿瘤同步放化疗患者口腔黏膜炎的预防和缓解具有积极作用,有助于控制炎症水平,降低同步放化疗对生活质量的影响.
Objective:To explore the influence of standardized oral care intervention on oral mucositis in patients with head and neck tumors undergoing concurrent chemoradiotherapy.Method:This study adopted a prospective research method.Totally 100 patients with head and neck tumors who received concurrent chemoradiotherapy in Taoyuan Branch,People's Hospital of Guangxi Zhuang Autonomous Region from July 2023 to July 2024 were divided into the control group(n=50)and the intervention group(n=50)according to the random number table method.Patients in both groups were treated with concurrent chemoradiotherapy for 5-6 weeks,during which corresponding care measures were given.The control group received routine care,and the intervention group implemented standardized oral care intervention on the basis of routine care.The incidence and severity of oral mucositis(WHO classification standard of oral mucositis)were compared between the two groups.The degree of oral pain in the two groups was evaluated by digital grading scale(NRS).The quality of life of the two groups was evaluated by quality of life questionnaire-core 30(QLQ-C30).The levels of inflammatory indicators in the two groups were evaluated.Result:The incidence and severity of oral mucositis in the intervention group were significantly lower than those in the control group(P<0.05).Three weeks after concurrent chemoradiotherapy and after its completion,the NRS scores of the intervention group were lower than those of the control group(P<0.05).After the completion of concurrent chemoradiotherapy,the functional scores of QLQ-C30 of the intervention group was higher than that of the control group,and the symptom scores was lower than that of the control group(P<0.05).Three weeks after concurrent chemoradiotherapy and after its completion,the IL-10 levels in the intervention group was lower than that in the control group,and the IL-12 levels was higher than that in the control group(P<0.05).Conclusion:Standardized oral care intervention plays a positive role in the prevention and relief of oral mucositis in patients with head and neck tumors undergoing concurrent chemoradiotherapy,which helps control the levels of inflammation and reduce the impact of concurrent chemoradiotherapy on the quality of life.
唐叶丹;石丽梅;梁娟;李春腾;甘海丽
广西壮族自治区人民医院桃源院区放疗二病区 广西 南宁 530000广西壮族自治区人民医院桃源院区放疗二病区 广西 南宁 530000广西壮族自治区人民医院桃源院区放疗二病区 广西 南宁 530000广西壮族自治区人民医院桃源院区放疗二病区 广西 南宁 530000广西壮族自治区人民医院桃源院区放疗二病区 广西 南宁 530000
标准化口腔护理头颈部肿瘤同步放化疗口腔黏膜炎炎症因子
Standardized oral careHead and neck tumorsConcurrent chemoradiotherapyOral mucosal inflammationInflammatory factors
《中国医学创新》 2026 (1)
85-90,6
广西壮族自治区卫生健康委自筹经费科研课题(Z-A20230023)
评论