百蕊颗粒对呼吸道合胞病毒感染肺组织中Th1/Th2细胞平衡及相关细胞因子表达的影响OA

Objective To explore the effect of Bairui granules on T helper(Th)1/Th2 cell balance and expression of related cytokines in lung tissues infected with respiratory syncytial virus(RSV).Methods Eighty pediatric patients with RSV pneumonia admitted to our hospital between June 2021 and June 2023 were randomly divided into control and trial groups.The control group received routine symp-tomatic treatment whereas the trial group received routine symptomatic treatment in combination with Bairui granules.Th1 and Th2 cells and related cytokines were detected in the peripheral blood of pediatric patients.In addition,48 young rats were randomly divided into the blank,RSV,and low-or high-dose Bairui granule groups.In this study,a rat model of RSV-infected pneumonia was established and treated with Bairui granules.The lung cofficient and RSV load in rat lung tissues were measured,and lung injury,Th1 and Th2 cells,and related factor levels in lung tissues were detected.Results Compared with the control group,the total effective rate in the trial group was improved;Th1 cells in the peripheral blood and serum levels of interferon(IFN)-γ,interleukin(IL)-2,and tumor necrosis factor(TNF)-α were increased,whereas Th2 cells and serum levels of IL-4,IL-5,and IL-13 were decreased(P<0.05).Compared with the blank group,rats in the RSV group showed severe pathological damage to the lung tissue,increased lung cofficient,viral load,Th2 cells,IL-4,IL-5,and IL-13 levels,and decreased Th1 cells and IFN-γ,IL-2,and TNF-α levels(P<0.05).Compared with the RSV group,rats in the low-and high-dose Bairui granule groups showed reduced lung tissue damage,lower lung cofficient,decreased viral load,reduced Th2 cell,IL-4,IL-5,and IL-13 levels,as well as increased Th1 cell,IFN-γ,IL-2,and TNF-α levels(P<0.05).Conclusion Bairui granules can regu-late Th1/Th2 cell balance and expression of related cytokines in RSV-infected lung tissues.