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2025年国内外免疫学研究重要进展OA

Major progress of immunology research in 2025

中文摘要英文摘要

2025年,免疫学研究在基础机制解析、学科交叉融合与临床转化应用等方面取得了系列突破性进展.在系统层面,免疫系统与神经、内分泌、消化道、心血管等多系统间的交互调控网络被进一步揭示;在微观层面,对免疫细胞内RNA与蛋白质互作、新型细胞死亡方式、物质和能量代谢等分子事件的理解也持续深化.这些进展显著深化了对免疫系统分化发育、功能调控及其在相关疾病中作用机制的理解.同时,基于免疫学原理开发的新技术与新策略为重大疾病诊断与治疗开辟了更广阔路径,尤其在肿瘤免疫治疗领域取得重要进展.本文梳理并遴选了2025年国内外免疫学领域的代表性研究成果,以期共同展望本学科的前沿发展方向.

The year 2025 has witnessed remarkable progress in immunology research,with pivotal breakthroughs in under-standing fundamental mechanisms,fostering interdisciplinary collaborations,and advancing clinical translations.Significant progress has been made in elucidating the interactive regulatory networks that connect the immune system to the nervous,endocrine,digestive,and cardiovascular systems.The underlying molecular mechanisms including RNA-protein interactions,emerging forms of cell death,and immunometabolic interplay have also been further clarified.These advances have significantly deepened our knowledge of immune development,function and regulation,and outlined promising directions for understanding the pathogenesis and developing new thera-peutic strategies for treatment of immune related diseases such as autoimmunity and cancer.This article reviews representative achieve-ments in immunology research in 2025 and discusses future directions for the field.

刘娟;曹雪涛

海军军医大学免疫学研究所暨免疫与炎症全国重点实验室,上海 200433海军军医大学免疫学研究所暨免疫与炎症全国重点实验室,上海 200433||中国医学科学院免疫治疗研究中心,北京 100005

医药卫生

免疫代谢免疫调控神经免疫肿瘤免疫肠道免疫免疫衰老

ImmunometabolismImmune regulationNeuroimmunologyTumor immunologyIntestinal immunityImmunose-nescence

《中国免疫学杂志》 2026 (1)

1-12,12

国家自然科学基金(92374115).

10.3969/j.issn.1000-484X.2026.01.001

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