抗菌聚乙烯醇纳米纤维敷料制备及性能研究OA

Wound dressings play a critical role in the healing process.This study developed a series of wound dressings with potent and long-lasting antimicrobial properties using an electrospinning technique.Polyvinyl alcohol(PVA)served as the substrate,loaded with several antimicrobial agents.To enhance the antimicrobial performance of the PVA/Ag⁺nanofiber membrane,wormwood(WW)decoction was incorporated as a secondary agent,producing a PVA/Ag⁺/WW composite nanofiber membrane.Fourier-transform infrared spectroscopy confirmed the successful incorporation of worm-wood's active antimicrobial components into the fibers.Scanning electron microscopy further verified the presence of wormwood within the material.The incorporation of wormwood improved the membrane's wettability,reducing the wa-ter contact angle from 50.5 ° to 23.5 °.Antimicrobial assays demonstrated that with a wormwood decoction concentra-tion of 80%,the inhibition zone diameters for the PVA/Ag⁺/WW membrane against Staphylococcus aureus,Escherich-ia coli,and Candida albicans were 16.02 mm,16.29 mm,and 16.22 mm,respectively.Furthermore,the nanofiber membranes maintained effective antimicrobial activity for five weeks.In conclusion,this work successfully combined sil-ver ions and wormwood decoction to create a high-performance nanofiber membrane with enhanced and sustained antimi-crobial efficacy,showing great promise for application in wound dressings and other medical fields.