甘油三酯-葡萄糖相关指标与颈动脉粥样硬化斑块的相关性分析OA
Association between triglyceride glucose-related indices and carotid atherosclerostic plaque in people on health examination
目的 研究甘油三酯-葡萄糖(TyG)相关指标之间的关联及其对颈动脉粥样硬化斑块(CAP)的预测价值.方法 纳入2019年至2024年在西安交通大学第一附属医院健康医学科健康体检者82 674例.按照颈动脉超声检查结果提示是否存在CAP分为CAP组(33 040例)和无CAP组(49 634例).将TyG指数、甘油三酯-葡萄糖体质指数(TyG-BMI)、甘油三酯-葡萄糖腰围(TyG-WC)以及甘油三酯-葡萄糖腰围身高比(TyG-WHtR)分别作为连续变量和分类变量,其中这些指数的四分位数数据由低到高分为Q1～Q4组后,作为分类变量纳入多变量Logistic回归模型,以评估其与CAP之间的关系.绘制受试者工作特征(ROC)曲线并寻找cut-off值以评估TyG相关指标对CAP发生的预测价值.结果 作为连续变量分析时,TyG、TyG-BMI、TyG-WC和TyG-WHtR与CAP发生率的比值比(OR)及 95％置信区间(95％CI)分别为:1.148(1.117,1.181)、1.009(1.004,1.014)、1.004(1.003,1.006)、1.069(1.04,1.098).TyG、TyG-BMI、TyG-WC和TyG-WHtR均与CAP发生率呈正相关(P＜0.05).将这些指数的四分位数数据由低到高分为Q1～Q4组后,其与CAP的关联仍具有统计学意义(Q2～Q4的OR值分别为:TyG指数1.751、2.312、2.654;TyG-BMI:1.751、2.312、2.654;TyG-WC:1.150、1.300、1.450;TyG-WHtR:1.200、1.400、1.600,均P＜0.05).其中,TyG-WHtR对CAP的预测能力最强,其次是TyG-WC和TyG本身,而TyG-BMI指数的预测能力最弱,ROC曲线下面积分别为0.633、0.619、0.604、0.584.结论 TyG相关指标与CAP的形成存在显著正相关.其中,TyG-WHtR对识别CAP风险具有最高预测能力.
Objective To investigate the association between triglyceride glucose(TyG)-related indices and carotid atherosclerotic plaque(CAP),and to evaluate the predictive value of these indices for CAP.Methods A total of 82 674 individuals who underwent health check-ups at the Department of Health Medicine,The First Affiliated Hospital of Xi'an Jiaotong University,from 2019 to 2024 were included.Based on the carotid ultrasound results,they were divided into two groups:CAP group(33 040 cases)and non-CAP group(49 634 cases).TyG index,triglyceride and glucose and body mass index(TyG-BMI),triglyceride and glucose and waist circumference(TyG-WC),triglyceride and glucose and waist-to-height ratio(TyG-WHtR)were included as both continuous and categorical variables in the multivariate Logistic regression models to assess their relationships with CAP.The quartile data of these indices were categorized from low to high into Q1-Q4 groups.Receiver operating characteristic(ROC)curves were plotted to find cut-off values and evaluate the predictive value of TyG-related indices for CAP occurrence.Results When analyzed as continuous variables,TyG,TyG-BMI,TyG-WC,and TyG-WHtR were all positively correlated with CAP with odds ratios(OR)and 95％confidence intervals(95％CI)of 1.148(1.117,1.181),1.009(1.004,1.014),1.004(1.003,1.006),and 1.069(1.04,1.098),respectively(P＜0.05).After categorizing these indices into quartiles(Q1-Q4),their associations with CAP remained statistically significant(OR of Q2-Q4:TyG:1.751,2.312,2.654;TyG-BMI:1.751,2.312,2.654;TyG-WC:1.150,1.300,1.450;TyG-WHtR:1.200,1.400,1.600,all P＜0.05).Among them,TyG-WHtR had the strongest predictive power for CAP,followed by TyG-WC and TyG itself,while TyG-BMI had the weakest predictive power,with the largest area under the ROC curve being 0.633,0.619,0.604,and 0.584,respectively.Conclusion TyG-related indices show a significant positive correlation with the formation of CAP.Among these indices,TyG-WHtR has the highest predictive ability to identify CAP risk.
杨玉环;陈卓;王军;马茂
西安交通大学第一附属医院健康医学科,陕西西安 710061西安交通大学第一附属医院健康医学科,陕西西安 710061西安交通大学第一附属医院健康医学科,陕西西安 710061西安交通大学第一附属医院健康医学科,陕西西安 710061
医药卫生
颈动脉粥样硬化斑块(CAP)甘油三酯-葡萄糖(TyG)指数甘油三酯-葡萄糖体质指数(TyG-BMI)甘油三酯-葡萄糖腰围(TyG-WC)甘油三酯-葡萄糖腰围身高比(TyG-WHtR)胰岛素抵抗(IR)
《西安交通大学学报（医学版）》 2026 (1)
109-117,9
陕西省自然科学基金青年项目(No.2019SF-026)陕西省自然科学基金面上项目(No.2024SF-YBXM-097)西安交通大学第一附属医院临床研究项目(No.XJTU1AF2023LSL-019)Supported by the Natural Science Foundation of Shaanxi Province(No.2019SF-026),the Natural Science Foundation of Shaanxi Province(No.2024SF-YBXM-097),and Clinical Research Award of The First Affiliated Hospital of Xi'an Jiaotong University(No.XJTU1AF2023LSL-019)
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