纳米载体技术包裹表棓儿茶酚棓酸酯/阿魏酸/乙酰基八肽-3经皮渗透、抗氧化及抗炎作用研究OA

Nanocarrier-based epicatechin gallate/ferulic acid/acetyl octapeptide-3 complexes(EFA-NCs)were prepared using nanocarrier conjugation technology.The transdermal absorption of EFA-NCs was evaluated using diffusion chamber experiments with an ex vivo porcine skin model.The antioxidant and anti-inflammatory properties were assessed through DPPH radical scavenging assays and cellular oxidative stress and inflammation models.Results demonstrated that EFA-NCs significantly enhanced the skin retention of active compounds and promoted their rapid and efficient delivery into deep dermal tissues.Antioxidant evaluations revealed that EFA-NCs effectively scavenged DPPH radicals,markedly reduced malondialdehyde(MDA)levels—a marker of oxidative damage—and increased the activities of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px).Anti-inflammatory studies further indicated that EFA-NCs significantly inhibited the secretion of inflammatory cytokines IL-1β,IL-8,and IL-6.These findings highlight the potential of EFA-NCs as multifunctional nanocarriers for enhancing dermal delivery and improving antioxidant and anti-inflammatory performance in cosmetic and dermatological applications.