Integrative omics and multi-cohort identify IRF1 and biological targets related to sepsis-associated acute respiratory distress syndromeOA
Integrative omics and multi-cohort identify IRF1 and biological targets related to sepsis-associated acute respiratory distress syndrome
Jiajin Chen;David C.Christiani;Feng Chen;Ruyang Zhang;Ruili Hou;Xiaowen Xu;Ning Xie;Jiaqi Tang;Yi Li;Xiaoqing Nie;Nuala J.Meyer;Li Su
Institute of Cardiovascular Diseases,Xiamen Cardiovascular Hospital of Xiamen University,Xiamen University School of Medicine,Xiamen,Fujian 361006,China||Department of Biostatistics,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China||China International Cooperation Center for Environment and Human Health,Nanjing Medical University,Nanjing,Jiangsu 211166,ChinaDepartment of Environmental Health,Harvard T.H.Chan School of Public Health,Boston,MA 02115,USA||Pulmonary and Critical Care Division,Department of Medicine,Massachusetts General Hospital and Harvard Medical School,Boston,MA 02114,USADepartment of Biostatistics,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China||China International Cooperation Center for Environment and Human Health,Nanjing Medical University,Nanjing,Jiangsu 211166,ChinaDepartment of Biostatistics,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China||China International Cooperation Center for Environment and Human Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China||Changzhou Medical Center,Nanjing Medical University,Changzhou,Jiangsu 213164,ChinaDepartment of Biostatistics,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China||China International Cooperation Center for Environment and Human Health,Nanjing Medical University,Nanjing,Jiangsu 211166,ChinaDepartment of Biostatistics,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China||China International Cooperation Center for Environment and Human Health,Nanjing Medical University,Nanjing,Jiangsu 211166,ChinaDepartment of Biostatistics,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China||China International Cooperation Center for Environment and Human Health,Nanjing Medical University,Nanjing,Jiangsu 211166,ChinaDepartment of Biostatistics,Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China||China International Cooperation Center for Environment and Human Health,Nanjing Medical University,Nanjing,Jiangsu 211166,ChinaDepartment of Biostatistics,University of Michigan,Ann Arbor,MI 48109,USAInstitute of Cardiovascular Diseases,Xiamen Cardiovascular Hospital of Xiamen University,Xiamen University School of Medicine,Xiamen,Fujian 361006,ChinaPulmonary,Allergy,and Critical Care Medicine Division,University of Pennsylvania Perelman School of Medicine,Philadelphia,PA 19104,USADepartment of Environmental Health,Harvard T.H.Chan School of Public Health,Boston,MA 02115,USA
医药卫生
acute respiratory distress syndromesepsisinterferon regulatory factor 1causal inferenceimmunity
acute respiratory distress syndromesepsisinterferon regulatory factor 1causal inferenceimmunity
《生物医学研究杂志（英文版）》 2026 (1)
11-22,12
This study was supported by the National Natural Science Foundation of China(Grant No.82220108002 to F.C.and Grant No.82273737 to R.Z.),the U.S.National Institutes of Health(Grant Nos.CA209414,HL060710,and ES000002 to D.C.C.Grant Nos. CA209414 and CA249096 to Y.L.),and the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD). R.Z. was partially supported by the Qing Lan Project of the Higher Education Institutions of Jiangsu Province and the Outstanding Young Level Academic Leadership Training Program of Nanjing Medical University.
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