针刺联合益肾强肝抗疲方治疗慢性疲劳综合征的疗效及对患者血清炎症因子、血脂指标的影响OA
Clinical efficacy of acupuncture combined with Yishen Qianggan Kangpi Formula in treating patients with chronic fatigue syndrome and its impacts on serum inflammatory factors and blood lipid indicators
目的 观察针刺联合益肾强肝抗疲方治疗慢性疲劳综合征的临床疗效及对患者血清炎症因子、血脂指标的影响.方法 选取2021 年8 月至2023 年7 月收治的118 例慢性疲劳综合征患者为研究对象,按照随机数字表法分为联合治疗组和汤药治疗组,每组 59 例.汤药治疗组予益肾强肝抗疲方治疗,联合治疗组在汤药治疗组的基础上联合针刺治疗.2 组均治疗 30d后统计疗效,比较 2 组治疗前后中医证候评分、血清炎性因子[包括白细胞介素 6(IL-6)、干扰素-γ(IFN-γ)、肿瘤坏死因子α(TNF-α)]、血脂指标[包括总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)]、疲劳程度[采用疲劳量表-14(FS-14)及疲劳评定量表(FAI)评定]、睡眠和焦虑症状[采用匹兹堡睡眠质量指数(PSQI)及汉密尔顿焦虑量表(HAMA)评价]变化情况.结果 联合治疗组总有效率 84.75%(50/59),汤药治疗组总有效率69.49%(41/59),联合治疗组疗效优于汤药治疗组(P<0.05).与本组治疗前比较,治疗后2 组中医证候总评分均显著低于治疗前(P<0.05),且治疗后联合治疗组中医证候评分显著低于汤药治疗组(P<0.05).与本组治疗前比较,治疗后 2 组IL-6、IFN-γ、TNF-α水平均显著低于治疗前(P<0.05),且治疗后联合治疗组IL-6、IFN-γ、TNF-α水平显著低于汤药治疗组(P<0.05).与本组治疗前比较,治疗后 2 组HDL-C显著高于治疗前(P<0.05),TC、TG、LDL-C均显著低于治疗前(P<0.05),且治疗后联合治疗组HDL-C显著高于汤药治疗组(P<0.05),TC、TG、LDL-C显著低于汤药治疗组(P<0.05).与本组治疗前比较,治疗后 2 组FS-14 评分、FAI评分均显著低于治疗前(P<0.05),且治疗后联合治疗组FS-14、FAI评分显著低于汤药治疗组(P<0.05).与本组治疗前比较,治疗后 2 组PSQI评分、HAMA评分均显著低于治疗前(P<0.05),且治疗后联合治疗组PSQI、HAMA评分显著低于汤药治疗组(P<0.05).结论 针刺联合益肾强肝抗疲方治疗慢性疲劳综合征可显著降低患者的中医证候评分,纠正脂代谢异常,缓解患者疲劳程度,改善患者睡眠质量和焦虑情绪,疗效显著.
Objective To analyze the clinical efficacy of acupuncture combined with Yishen Qianggan Kangpi Formula in treating patients with chronic fatigue syndrome,and its impacts on serum inflammatory factors and blood lipid indicators.Methods A total of 118 patients with chronic fatigue syndrome visited our hospital from August 2021 to July 2023 were enrolled.They were randomized 1:1 to Yishen Qianggan Kangpi Formula(decoction treatment group)or acupuncture combined with Yishen Qianggan Kangpi Formula(combined treatment group)for 30 days.The clinical efficacy of two groups was recorded,and the traditional Chinese medicine(TCM)syndrome scores,serum inflammatory factor levels including interleukin-6(IL-6),interferon-γ(IFN-γ),tumor necrosis factor-α(TNF-α),blood lipid index levels including total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),fatigue level scores including Fatigue Scale-14(FS-14)and Fatigue Assessment Instrument(FAI),and sleep quality and anxiety scores including Pittsburgh Sleep Quality Index(PSQI)and Hamilton Anxiety Scale(HAMA)were included as comparisons.Results The total effective rate in the combined treatment group was significantly higher than that of the decoction treatment group(84.75%[50/59]vs 69.49%[41/59],P<0.05).After treatment,the both groups had significantly lower TCM syndrome scores,IL-6,IFN-γ,TNF-α,TC,TG,and LDL-C levels,higher HDL-C,decreased FS-14,FAI,PSQI and HAMA scores relative to before treatment(all P<0.05),and the combined treatment group was superior to the decoction treatment group for the above indexes(all P<0.05).Conclusion Acupuncture combined with Yishen Qianggan Kangpi Formula can efficiently reduce TCM syndrome score of patients with chronic fatigue syndrome,correct abnormal lipid metabolism,alleviate fatigue,improve sleep quality and anxiety,with an obvious therapeutic effect.
高骐翔;万敏;汪亚莉
湖北省武汉市中医医院检验科,湖北 武汉 430000湖北省武汉市中医医院检验科,湖北 武汉 430000长江航运总医院·武汉脑科医院检验科,湖北 武汉 430000
医药卫生
慢性疲劳综合征针刺疗法中药疗法
Chronic fatigue syndromeAcupunctureTraditional Chinese medicine therapy
《河北中医》 2026 (1)
127-131,5
武汉市卫生健康委中医药科研项目(编号:360.1047)
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