调气化浊法治疗慢性阻塞性肺疾病急性加重期合并2型糖尿病痰瘀互结兼气阴两虚证临床研究OA

Objective To observe the clinical effect of regulating gasification and turbidity on acute exacerbation of chronic obstructive pulmonary disease(AECOPD)patients with type 2 diabetes mellitus(T2DM)in the syndrome of phlegm and blood stasis plus Qi and Yin deficiencies.Methods A total of 96 AECOPD patients with T2DM in the syndrome of phlegm and blood stasis plus Qi and Yin deficiencies treated in the Department of Pulmonary Diseases(68 cases)and Department of Diabetes(28 cases)of Huaibei Hospital of Traditional Chinese Medicine from October 2022 and December 2023 were included.They were randomly divided into the treatment group and control group,with 48 cases in each group.Patients in both groups received routine Western medicine treatment,while those in the treatment group additionally received Chaiting Ningfei Granules and Danzhi Jiangtang Capsules.The TCM syndrome scores,lung function,blood gas analysis,blood glucose indicators,the fear of progression questionnaire--short form in Chinese version(FoP-Q-SF),the COPD Assessment Test(CAT),and safety indicators were compared between the two groups before and after treatment.Results After treatment,TCM syndrome,FoP-Q-SF and CAT scores,and blood sugar indicators(glycated hemoglobin[HbA1c],fasting plasma glucose[FPG],and 2 h postprandial blood sugar[2 hPG])were significantly reduced in both groups(P<0.05),which were significantly lower in the treatment group than the control group(P<0.05).After treatment,the forced vital capacity(FVC),forced expiratory volume in the first second(FEV1),and FEV1/FVC were significantly elevated in both groups(P<0.05),which were significantly higher in the treatment group than the control group(P<0.05).After treatment,significantly higher oxygen partial pressure(PaO2)and oxygen saturation(SaO2),and lower carbon dioxide partial pressure(PaCO2)were detected in both groups(P<0.05),which were significantly pronounced in the treatment group than the control group(P<0.05).No adverse reactions occurred during the clinical trial in both groups.Conclusion For AECOPD patients with T2DM,regulating gasification and turbidity can effectively improve lung function,blood gas indexes,blood sugar indexes,quality of life and TCM syndrome scores,and with high safety.