脑类淋巴系统相关中枢神经系统疾病中gBOLD-CSF耦合异常的研究进展OA
Research progress of abnormal gBOLD-CSF coupling in brain glymphatic system related central nervous system diseases
类淋巴系统(glymphatic system,GS)是大脑中废物清除的途径,其功能受损与多种中枢神经系统疾病密切相关.静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)研究发现,低频(<0.1 Hz)全脑血氧水平依赖(global blood oxygen level-dependent,gBOLD)信号与脑脊液(cerebrospinal fluid,CSF)动力学存在耦合,且与GS功能相关,这一现象为揭示脑类淋巴功能障碍提供新的方向.本文就GS的介绍、gBOLD-CSF耦合原理及其在中枢神经系统疾病中的应用进行综述,旨在梳理多种中枢神经系统疾病GS功能变化的研究,明确gBOLD-CSF耦合异常在中枢神经系统疾病病情判断及疗效评估等方面的研究价值与前景.同时,本文指出了当前研究的局限性并提出了今后研究的方向.
The glymphatic system(GS)is a waste clearance pathway in the brain,and its impaired function is closely associated with various central nervous system diseases.Resting-state functional magnetic resonance imaging(rs-fMRI)studies have revealed that low-frequency(<0.1 Hz)global blood oxygen level-dependent(gBOLD)signals are coupled with cerebrospinal fluid(CSF)dynamics,a phenomenon that is related to GS function and provides a new direction for uncovering brain glymphatic dysfunction.This review summarizes the key aspects of the GS,the principles of gBOLD-CSF coupling,and its applications in central nervous system diseases.It aims to synthesize research on GS functional changes in a range of central nervous system disorders,and to clarify the value and prospects of abnormal gBOLD-CSF coupling for assessing disease severity and evaluating treatment efficacy.Meanwhile,this review identifies the limitations of current research and proposes directions for future studies.
苏婧;王祎;安宁宁;杨龙飞;苏琦;张宇彤;张清
大连大学附属中山医院放射科,大连 116001大连大学附属中山医院放射科,大连 116001大连大学附属中山医院放射科,大连 116001大连大学附属中山医院放射科,大连 116001大连大学附属中山医院放射科,大连 116001大连大学附属中山医院放射科,大连 116001大连大学附属中山医院放射科,大连 116001
医药卫生
中枢神经系统疾病类淋巴系统脑脊液全脑静息态功能磁共振成像信号磁共振成像
central nervous system diseasesglymphatic systemcerebrospinal fluidglobal resting-state functional magnetic resonance imaging signalmagnetic resonance imaging
《磁共振成像》 2026 (1)
140-145,161,7
Liaoning Provincial Department of Education Project in Natural Sciences(No.jyt-dldxfw202006). 辽宁省教育厅自然科学类项目(编号:jyt-dldxfw202006)
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