猪繁殖与呼吸综合征防控与净化研究进展OA

Porcine reproductive and respiratory syndrome(PRRS)is a contagious disease caused by the porcine reproductive and respiratory syndrome virus(PRRSV),which has a negative impact on the sustainable and healthy development of the pig industry.Developing regional purification is an effective way to control PRRS.This article systematically discusses the characteristics of PRRSV,the current status of PRRS prevention and control,and the research progress of PRRS purification.PRRSV is an enveloped spherical single-stranded positive-sense RNA virus with strong mutation and recombination ability,diverse and complex genetic background,and both antibody-dependent enhancement and persistent infection characteristics,making its comprehensive prevention and control difficult.Currently,common prevention and control measures include vaccination and drug treatment.Inactivated vaccines,attenuated vaccines,and new vaccines(subunit vaccines,nucleic acid/mRNA vaccines,etc.)can all effectively reduce the risk of PRRSV infection.Natural compounds such as dicoumarol and morin C,as well as Chinese herbal extracts such as Scutellaria baicalensis polysaccharides and Isatis indigotica polysaccharides,all have anti-PRRSV effects.Implementing regional purification of PRRS is an important means to control PRRSV.Currently,most pig farms are actively exploring the establishment of PRRS purification models for large-scale farms,and the number of successfully purified PRRS farms is increasing year by year.PRRS regional purification includes improving the biosecurity system through measures such as physical isolation,personnel control,material disinfection,and harmless treatment;selecting appropriate purification strategies such as thorough depopulation and repopulation,testing and culling,and closed purification,while also supplemented by regular and continuous testing to ensure and consolidate the purification results.This article provides a reference for the prevention and control and purification of PRRS.