复方枸杞熏蒸制剂超声雾化治疗轻中度睑板腺功能障碍型干眼肝肾阴虚证的临床观察OA
Clinical Observation on the Efficacy of Ultrasonic Nebulization Therapy with Compound Lycium Scorzonera Steam Inhalation Preparation for Mild to Moderate Meibomian Gland Dysfunction-Type Dry Eye Syndrome with Liver-Kidney Yin Deficiency Pattern
目的 观察复方枸杞熏蒸制剂超声雾化对轻中度睑板腺功能障碍(MGD)型干眼症肝肾阴虚证的临床疗效.方法 选取符合纳入标准的轻中度MGD型干眼症肝肾阴虚证患者,依据随机数字表随机分为对照组和中药组,每组各40例.对照组给予睑板腺按摩、0.3%玻璃酸钠滴眼液联合生理盐水雾化治疗,中药组使用复方枸杞熏蒸制剂替代生理盐水雾化治疗,其余治疗同对照组,两组均每次雾化20 min,每周雾化2次,共治疗4周.观察治疗前后泪膜破裂时间(BUT)、角膜应该染色(FL)评分、泪液pH值、睑板腺开口和分泌物评分、眼表疾病指数(OSDI)评分和中医证候积分的变化情况,并比较临床疗效.结果 中药组临床总有效率95%(38/40),明显高于对照组67.5%(27/40)(P<0.01).与治疗前比较,中药组治疗后BUT延长,泪液pH值、FL、OSDI、睑板腺开口和分泌物评分和中医证候积分均降低,对照组治疗后BUT延长,泪液pH值、FL、OSDI、睑板腺开口评分均降低(P<0.01),且中药组治疗后上述指标改善情况优于对照组(P<0.01).结论 复方枸杞熏蒸制剂超声雾化联合眼睑按摩能提高睑板腺功能障碍型肝肾阴虚证患者的治疗效果,改善睑板腺功能,减轻炎症反应,稳定眼表微环境.
Objective To observe the clinical efficacy of ultrasonic nebulization with Compound Lycium Scorzonera Steam Inhalation Preparation in the treatment of mild to moderate meibomian gland dysfunction(MGD)-type dry eye syndrome with liver-kidney yin deficiency pattern.Methods Patients of mild to moderate MGD-type dry eye syndrome with liver-kidney yin deficiency pattern who met the inclusion criteria were selected and randomly divided into a control group and a TCM group using a random number table,with 40 cases in each group.The control group received meibomian gland massage and 0.3%sodium hyaluronate eye drops,in addition to nebulization therapy with physiological saline.The TCM group received the same base regimen but with the physiological saline nebulization replaced by ultrasonic inhalation of the Compound Lycium Scorzonera Steam Inhalation Preparation.Each nebulization session lasted 20 minutes,administered twice per week for a total treatment duration of 4 weeks for both groups.Changes in breakup time of tear film(BUT),fluorescein(FL)staining scores,pH values of tear,meibomian gland orifice and secretion scores,Ocular Surface Disease Index(OSDI)scores,and TCM syndrome scores were observed before and after treatment,and the clinical efficacy was compared between the two groups.Results The total clinical effective rate of the TCM group was 95%(38/40),which was significantly higher than 67.5%(27/40)of the control group(P<0.01).Compared with before treatment,after treatment in the TCM group,BUT was prolonged,while tear pH values,FL scores,OSDI scores,meibomian gland orifice and secretion scores,and TCM syndrome scores were all decreased.In the control group,after treatment,BUT was prolonged,while tear pH values,FL scores,OSDI scores,and meibomian gland orifice scores were decreased(P<0.01).Moreover,the improvement of all indicators in the TCM group after treatment was superior to that in the control group(P<0.01).Conclusion Ultrasonic nebulization with Compound Lycium Scorzonera Steam Inhalation Preparation combined with eyelid massage can improve the therapeutic effect in patients of mild to moderate MGD-type dry eye syndrome with liver-kidney yin deficiency pattern,enhance meibomian gland function,reduce inflammatory response,and stabilize the ocular surface microenvironment.
方娜;姚菊英
南京中医药大学附属苏州市中医医院,江苏 苏州 215009南京中医药大学附属苏州市中医医院,江苏 苏州 215009
复方枸杞熏蒸制剂干眼症睑板腺功能障碍肝肾阴虚证
Compound Lycium Scorzonera Steam Inhalation PreparationDry eye syndromeMeibomian gland dysfunctionLiver-kidney yin deficiency pattern
《中医药信息》 2026 (2)
60-64,5
江苏省苏州市科技局指导性项目(SKJYD2021127)
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