基于因子与聚类分析的多囊卵巢综合征中医证候分布规律研究OA

Objective To analyze the distribution patterns of traditional Chinese medicine(TCM)syndromes in polycystic ovary syndrome(PCOS)based on multicenter large-scale data and establish a pathogenic classification framework to provide a basis for precise clinical differentiation.Methods A multicenter cross-sectional study design was employed,enrolling 936 PCOS patients from seven Tertiary A hospitals.A standardized TCM syndrome questionnaire was designed through literature mining and Delphi expert consultation.Frequency analysis was used to extract core symptoms,factor analysis to identify syndrome elements,and core syndrome patterns were summarized by the K-means clustering algorithm.Results High-frequency symptoms predominantly included soreness and weakness of waist and knees,oily skin,depressive mood with frequent sighing,and acne.The primary pathogenesis location factors were identified as the kidney,lung/large intestine,and thoroughfare vessel,with damp-heat,blood stasis,and yin deficiency as the key pathogenesis nature factors.Cluster analysis identified five major syndrome patterns:kidney yin deficiency with damp-heat,spleen deficiency with phlegm-dampness,qi stagnation with blood stasis,dampness-heat and blood stasis obstructing,and kidney yang deficiency with phlegm-dampness,covering 97.86%of cases.Conclusion This study established five core PCOS syndrome patterns dominated by kidney yin deficiency with damp-heat,spleen deficiency with phlegm-dampness,qi stagnation with blood stasis,dampness-heat and blood stasis obstructing,and kidney yang deficiency with phlegm-dampness,providing data support for syndrome standardization.Meanwhile,the pathogenic significance of disease-location elements"thoroughfare vessel"and"lung/large intestine"in PCOS pathogenesis should to be taken seriously.