自发性乳糜疾病患者PROX1、FOXC2和VEGFR3基因表达模式的研究OA

Objective To investigate the correlation between key lymphatic development genes prospero homeobox 1(PROX1),forkhead box protein C2(FOXC2),and vascular endothelial growth factor receptor 3(VEGFR3)in spontaneous chylous disorders.Methods A retrospective study was conducted from January 2019 to December 2023.Twenty-five patients with spontaneous chylous disorders were selected as the patient group,and 20 healthy volunteers undergoing physical examination during the same period were selected as the control group from Shanghai Pudong New Area Punan Hospital.Protein and mRNA expression levels of PROX1,FOXC2,and VEGFR3 in whole blood were compared between the two groups.Results Among the 25 patients with spontaneous chylous disorders,there were 11 cases of chyluria,6 cases of chylous ascites,and 8 cases of chylothorax.No statistically significant difference was found in whole blood protein expression levels of PROX1,FOXC2,and VEGFR3 between the control group and the patient group(P>0.05);However,mRNA expression levels of PROX1,FOXC2,and VEGFR3 were significantly higher in the patient group than in the control group(P<0.05).There were no statistically significant differences in PROX1 and FOXC2 expressions among patients with chyluria,chylothorax and chylous ascites(P>0.05).Conclusion The upregulation of PROX1,FOXC2,and VEGFR3 gene expression in spontaneous chylous diseases suggests that these genes may be involved in the occurrence and development of the disease by affecting lymphatic structure and function.