外周血抗米勒管激素和甲状腺特异性抗体检测对多囊卵巢综合征患者妊娠结局的预测价值OA
Predictive Value of Peripheral Blood Anti-Müllerian Hormone and Thyroid Specific Antibodies for Pregnancy Outcomes in Patients with Polycystic Ovary Syndrome
目的 探究外周血抗米勒管激素(AMH)和甲状腺特异性抗体检测对多囊卵巢综合征(PCOS)患者妊娠结局的预测价值.方法 选取2022年1月至2024年1月重庆市江津区妇幼保健院收治的120例PCOS患者进行回顾性分析,所有患者均检测外周血AMH、促甲状腺激素(TSH)及甲状腺特异性抗体[甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)]水平.根据妊娠结局分为妊娠组(73例)及未妊娠组(47例),比较两组患者外周血AMH、TSH、TPOAb、TGAb水平;对已妊娠患者进行随访,根据妊娠结局分为妊娠结局良好组(44例)及妊娠结局不良组(29例),分析外周血AMH、TSH及甲状腺特异性抗体水平对妊娠结局的预测价值及对患者妊娠结局的影响.结果 未妊娠组AMH、TPOAb、TGAb水平高于妊娠组(P<0.05).妊娠结局不良组AMH、TPOAb、TGAb水平高于妊娠结局良好组(P<0.05).AMH及TPOAb、TGAb水平联合预测PCOS患者妊娠结局的曲线下面积高于各指标单独预测(均P<0.05).妊娠结局不良组中孕前身体质量指数≥25.00 kg/m2、妊娠期高血压、妊娠期糖尿病、AMH≥7.07 ng/mL、TPOAb≥70.89 IU/mL、TGAb≥58.88 IU/mL的患者占比高于妊娠结局良好组(P<0.05).妊娠期高血压、妊娠期糖尿病、AMH≥7.07 ng/mL、TPOAb≥70.89 IU/mL、TGAb≥58.88 IU/mL为PCOS患者妊娠结局的独立影响因素(P<0.05).结论 外周血AMH和TPOAb、TGAb水平异常升高为PCOS患者出现不良妊娠结局的独立影响因素,且上述指标联合检测对患者妊娠结局具有良好预测价值.
Objective To explore the predictive value of peripheral blood anti-Müllerian hormone(AMH)and thyroid-specific antibody levels on pregnancy outcomes in patients with polycystic ovary syndrome(PCOS).Methods A total of 120 patients with PCOS admitted to Jiangjin District Maternal and Child Health Hospital of Chongqing from January 2022 to January 2024 were included for retrospective analysis.All patients underwent detection of peripheral blood AMH,thyroid-stimulating hormone(TSH),and thyroid-specific antibodies[thyroid peroxidase antibody(TPOAb),thyroglobulin antibody(TGAb)].According to pregnancy outcomes,patients were divided into a pregnancy group(73 cases)and a non-pregnancy group(47 cases).The levels of peripheral blood AMH,TSH,TPOAb,and TGAb were compared between the two groups.The pregnant patients were followed up and further divided into a good pregnancy outcome group(44 cases)and a poor pregnancy outcome group(29 cases)based on their pregnancy outcomes.The predictive value of peripheral blood AMH,TSH,and thyroid-specific antibody levels on pregnancy outcomes and their influence on pregnancy outcomes were analyzed.Results The levels of AMH,TPOAb,and TGAb in the non-pregnancy group were higher than those in the pregnancy group(P<0.05).The levels of AMH,TPOAb,and TGAb in the poor pregnancy outcome group were higher than those in the good pregnancy outcome group(P<0.05).The area under the curve(AUC)of the combination of AMH,TPOAb,and TGAb for predicting pregnancy outcomes in PCOS patients was greater than that of each indicator alone(P<0.05).The proportions of patients with pre-pregnancy BMI≥25.00 kg/m²,gestational hypertension,gestational diabetes mellitus,AMH≥7.07 ng/mL,TPOAb≥70.89 IU/mL,and TGAb≥58.88 IU/mL in the poor pregnancy outcome group were higher than those in the good pregnancy outcome group(P<0.05).Gestational hypertension,gestational diabetes mellitus,AMH≥7.07 ng/mL,TPOAb≥70.89 IU/mL,and TGAb≥58.88 IU/mL were identified as independent influencing factors for pregnancy outcomes in PCOS patients(P<0.05).Conclusion Abnormally elevated levels of peripheral blood AMH,TPOAb,and TGAb are independent influencing factors for poor pregnancy outcomes in PCOS patients,and the combined detection of these indicators has good predictive value for pregnancy outcomes.
兰波;明露敏;张瑞伶;王燕;兰瑞伦;刘进
重庆市江津区妇幼保健院产科,重庆 402260重庆市江津区妇幼保健院产科,重庆 402260重庆市江津区妇幼保健院产科,重庆 402260重庆市江津区妇幼保健院产科,重庆 402260重庆市江津区妇幼保健院产科,重庆 402260重庆市江津区妇幼保健院产科,重庆 402260
多囊卵巢综合征抗米勒管激素甲状腺特异性抗体妊娠结局预测价值
polycystic ovary syndromeAnti-Müllerian Hormonethyroid specific antibodiespregnancy outcomespredictive value
《转化医学杂志》 2026 (1)
11-14,4
重庆市卫生健康委妇幼科研培育项目(2021FY113)
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