痧点放血结合针刺治疗气滞血瘀型神经根型颈椎病急性发作期:随机对照试验OA

Objective To observe the clinical effect of bloodletting at guasha marks(petechiae after scraping therapy)combined with acupuncture on acute attack of cervical spondylotic radiculopathy(CSR)differentiated as qi stagnation and blood stasis,and the effect of this combined therapy on serum inflammatory factors.Methods A total of 120 patients with CSR at the acute phase,differentiated as qi stagnation and blood stasis were randomly assigned into three groups,a group of bloodletting at guasha marks combined with acupuncture(guasha-mark bloodletting group,40 case,1 case dropped out),a group of the bloodletting at Dazhui(GV14)combined with acupuncture(GV14 bloodletting group,40 cases,2 cases were eliminated,1 case dropped out),and a western medication group(40 cases,2 cases were eliminated).In the guasha-mark bloodletting group,acupuncture was operated,combined with bloodletting at guasha marks on the shoulder and neck regions.Acupuncture was delivered at bilateral neck-Jiaji(EX-B2)from C4 to C7,Fengchi(GB20),Jing-bailao(EX-HN15),Jianjing(GB21),Jianwaishu(SI14),Dazhui(GV14)and ashi points,once daily,5 treatments a week.Scraping therapy was operated on the superficial area of the trapezius muscle from C4 to T7,and 2 or 3 spots with the most clear guasha marks were selected for bloodletting,delivered once every 3 days,twice a week.In the GV14 bloodletting group,the acupoint selection and the treatment procedure of acupuncture intervention were the same as the guasha-mark bloodletting group,but bloodletting was delivered at Dazhui(GV14)instead,once every 3 days,twice a week.In the western medication group,sodium diclofenac sustained release tablets were administered orally,once daily.One course of treatment was composed of 1 week of interventions,and 2 courses were required in each group.Before and after treatment,as well as in follow-up of 1 month after treatment completion,the scores of visual analogue scale(VAS)for cervical pain,neck disability index(NDI)and Japan Orthopaedic association(JOA)were observed in each group separately.Before and after treatment,using ELISA,the levels of serum inflammatory factors,i.e.interleukin(IL)-1β,IL-6 and tumor necrosis factor-α(TNF-α)were detected;and the clinical effect was evaluated after treatment in each group.Results After treatment and during follow-up,the VAS and NDI scores were all reduced in comparison with those before treatment in the three groups(P＜0.05),and the JOA scores were elevated(P＜0.05).Besides,the VAS and NDI scores in the guasha-mark bloodletting group were lower than those in the GV14 bloodletting group and the western medication group(P＜0.05),while,the JOA scores were higher(P＜0.05).In the follow-up,the VAS score in the GV14 bloodletting group was lower than that of the western medication group(P＜0.05).After treatment,in each group,the levels of serum IL-1β,IL-6 and TNF-α were reduced in comparison with those before treatment(P＜0.05);and the levels of serum IL-1β,IL-6 and TNF-α in the guasha-mark bloodletting group were lower than those in either the GV14 bloodletting group or the western medication group(P＜0.05).The levels of serum IL-1βand IL-6 in the GV14 bloodletting group were higher than those of the western medication group(P＜0.05).The total effective rate was 97.4%(38/39)in the guasha-mark bloodletting group,which was higher than that(86.5%,32/37)in the GV14 bloodletting group and that(89.5%,34/38)in the western medication group(P＜0.05).The healing rate was 84.6%(33/39)in the guasha-mark bloodletting group,higher than that(67.6%,25/37)in the GV14 bloodletting group and that(63.2%,24/38)in the western medication group(P＜0.05).Conclusion Guasha-mark bloodletting combined with acupuncture is effective on acute attack of CSR with qi stagnation and blood stasis.This combined therapy can reduce cervical pain,functional disorders,and the levels of serum inflammatory factors,showing a favorable long-term therapeutic effect.