铁死亡的发生机制及其在甲状腺癌中的研究进展OA

Thyroid cancer(TC)is the most common malignant tumor in the endocrine system and the head and neck region.During the period from 2003 to 2012,the incidence rate of thyroid cancer in our country increased by an average of 20.4%per year and showed a trend of becoming younger.Data from the World Health Organization shows that in 2020,there were approximately 580,000 new cases worldwide,with China accounting for about one-third(around 200,000 cases).Ferroptosis,as a novel form of programmed cell death,is involved in a series of pathophysiological processes regulated by mechanisms such as iron metabolism,lipid metabolism,and glutathione redox.Research on the mechanisms of ferroptosis has revealed certain similarities with TC in pathophysiology.Based on this,this paper discusses the mechanisms of ferroptosis and its potential pathogenic mechanisms in TC,aiming to provide new ideas for basic research on ferroptosis and clinical treatment of TC.